Protein Alignment CG31213 and ABCA8

DIOPT Version :9

• Sequence 1: NP_001262752.1
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_001275914.1
• Gene: ABCA8 / 10351
• HGNCID: 38
• Length: 1621
• Species: Homo sapiens
• Alignment Length: 1865
• Identity: 418/1865 - (22%)
• Similarity: 778/1865 - (41%)
• Gaps: 404/1865 - (21%)

  Fly     3 RNLTYCQKYRLLL-------WKDIKLQLTNWVELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEM 60
            |.::.||:...||       |:..:..|..|:..::::....:.|....:..  ..|:...|:..
Human     4 RKISVCQQTWALLCKNFLKKWRMKRESLMEWLNSLLLLLCLYIYPHSHQVND--FSSLLTMDLGR 66

  Fly    61 EKSPGPKSVNTSLFVDLYFTPNNGILEQLITQLA-----------------NISEFKS------V 102
                 ..:.|.|.| .:.:||.....:|::.::|                 :|.||.:      |
Human    67 -----VDTFNESRF-SVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYPEEIV 125

  Fly   103 EVFDTNSELY-LQLMINRNAIGIAFPSEWYD-IKSCPEVLNLTIFMPLSIKRKDFKYFESGFLLL 165
            .|..||:..| |:.::..   |:....|..| ...|.|. |..::..:|:      :::.||:.|
Human   126 RVTFTNTYSYHLKFLLGH---GMPAKKEHKDHTAHCYET-NEDVYCEVSV------FWKEGFVAL 180

  Fly   166 QERISKIFIFFKNAGNGKIPRVLMNHFPYPSYVPNHYAESAKAMTYMTLIS--------FFLPC- 221
            |..|           |..|..:..||    |.:....:.:.|.|...:.|.        :...|
Human   181 QAAI-----------NAAIIEITTNH----SVMEELMSVTGKNMKMHSFIGQSGVITDLYLFSCI 230

  Fly   222 ITIAKYV------VAEKERHQKAVLTAMGFSNSIHWLAW---YTKSMLL--LLLCLLIMISIFSI 275
            |:.:.::      |..:.:..||::|.||..:|..||:|   |...:.:  |.|.|:|..:.|.|
Human   231 ISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFII 295

  Fly   276 GLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRS-LSAVVATILMYFSTALPFLIVGAENSS 339
                 .|..:.:.::||:|..|||..||.:|....:| |:.:|..:|..|...|.|       :|
Human   296 -----LSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLTGLVVFLLTVFWGCLGF-------TS 348

  Fly   340 VAAQTAAS----IGLNSALFYILDSVAVMEMQSVGAQWYTIDNTA----SSGYKLSIVGYMLIMI 396
            :.....||    :.|.|...::|....::.:.      |.:::.|    |.|..| ||....::.
Human   349 LYRHLPASLEWILSLLSPFAFMLGMAQLLHLD------YDLNSNAFPHPSDGSNL-IVATNFMLA 406

  Fly   397 SISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGNLPA 461
            ..:.:.|.:.:|.|.:...|:...:|..:..:..:|...:....|    ||        |..:.|
Human   407 FDTCLYLALAIYFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHV----AL--------EDEMDA 459

  Fly   462 AHPTRQPIIYLDDRTQENFQRV--NISKKIGIEVRSLSKTFGFR----NVVKDLFFNVYENEITA 520
                       |....::|::.  ....|..|.:|:::|.:..:    ..:|||.|::||.:|||
Human   460 -----------DPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKGKPDKIEALKDLVFDIYEGQITA 513

  Fly   521 LVGHKGSGKTTIIMMLCGILQPTTGTVLI--NGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDH 583
            ::||.|:||:|::.:|.|:..||.|:|.|  |....:.:.:......|:|||.:|.|..::.|::
Human   514 ILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKLSEMADLENLSKLTGVCPQSNVQFDFLTVREN 578

  Fly   584 IYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEP 648
            :..|:::||....|...|....:.:|.:.:.|...|..||.|.:|:|:...|:....::.|.|||
Human   579 LRLFAKIKGILPQEVDKEIQRVLLELEMKNIQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLDEP 643

  Fly   649 SSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFT 713
            ::||||..||::...|::.|..|.||.:||.::|.:|||||...::.|::.|.|:..:||:....
Human   644 TAGLDPFSRHQVWNLLKERKTDRVILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGI 708

  Fly   714 SYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGVDVSYKLPRSQIDRFPEFFQQLEENKKSLN 778
            .|.||.|:......:|:|.||:.::............:.|.||..:.::|||.::.| ::...|.
Human   709 GYHLSLQLNEICVEENITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELYKDL-DSYPDLG 772

  Fly   779 VVSFGVSDSTLDGIYLSLDYGQGSSRLRGGADPGVNDKVEFG-VQTDKAIRTKDRANNSLVRYQH 842
            :.::|||.:||:.::|.|   :|.|.:      ..:|....| ||.:||..|:     .||..:.
Human   773 IENYGVSMTTLNEVFLKL---EGKSTI------NESDIAILGEVQAEKADDTE-----RLVEMEQ 823

  Fly   843 QVDPPNETILNTKTPINPIEIWRPIDREKGSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYY 907
            .:...|:    .:..|..:.:|    |::...:|:.:.:.:|.:.    :||:.:|::::..|..
Human   824 VLSSLNK----MRKTIGGVALW----RQQICAIARVRLLKLKHER----KALLALLLILMAGFCP 876

  Fly   908 IIVLGTAAS--------EKCAH----RTDKQPVLPLSLDYYSYDDMIILLEVDKQLYKSEGEAYV 960
            ::|..|...        |...|    ...:||          :|.:..||.::|.  .:..:.::
Human   877 LLVEYTMVKIYQNSYTWELSPHLYFLAPGQQP----------HDPLTQLLIINKT--GASIDDFI 929

  Fly   961 QLVKEPATVESVDSIFSHLLKAPPIIRRDIKRKYVCGASFNNASTITAWFNSDAFEHSA------ 1019
            |.|:.......||:..:              |......|:|.|  ||...|...:..|.
Human   930 QSVEHQNIALEVDAFGT--------------RNGTDDPSYNGA--ITVCCNEKNYSFSLACNAKR 978

  Fly  1020 ----PIALNLVYNA-LGKAVFEDQDFSILVNRGDLHDFIWLNNASSMRRRYKRQNDPDYTDYSDY 1079
                |:.:::|.|. ||
Human   979 LNCFPVLMDIVSNGLLG------------------------------------------------ 995

  Fly  1080 EIQEYDVVVKPN-----SSSTSGQHNKSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLFGTLII 1139
                   :|||:     ..||..::.:.||                                 |.
Human   996 -------MVKPSVHIRTERSTFLENGQDNP---------------------------------IG 1020

  Fly  1140 ITAYIALCLSIFSI---FVTKERVEHFK----MQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALT 1197
            ..|||...|.:.|.   ::....::.:|    .|..|.|::...:|....:.|..:|.:....:.
Human  1021 FLAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIY 1085

  Fly  1198 IAIYHFTIWYQVVVMLLLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTGGMLFSFMYMLTLI 1262
            :..|.......::.::.:|...| ...|..||:|....|:|  ||.......|:.....|::|:.
Human  1086 LMSYISNFEDMLLTIIHIIQIPC-AVGYSFSLIFMTYVISF--IFRKGRKNSGIWSFCFYVVTVF 1147

  Fly  1263 TDVNFT-TVFAILPMYVGTFGLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPERTWMEV 1326
            :...|. ::|.....::.||               ::||...:.|.|.:.::..:.......|:|
Human  1148 SVAGFAFSIFESDIPFIFTF---------------LIPPATMIGCLFLSSHLLFSSLFSEERMDV 1197

  Fly  1327 ---------------WLLMVHCLVWFIFLWFSNFG-----YEIGYRFKPKLSNRIWHNNE----- 1366
                           :|..:.||.|       .||     .:..:|..|: |:.:..|.|
Human  1198 QPFLVFLIPFLHFIIFLFTLRCLEW-------KFGKKSMRKDPFFRISPR-SSDVCQNPEEPEGE 1254

  Fly  1367 -KHIRVLDEERRVGLIPKYEHEDYPIIVDQ-VTKNYC--------RAKN--AVQLVSFAIRPGDT 1419
             :.:: ::..|....:.....::.|:|:.. :.|.|.        :.||  |.:.|||.:|.|:.
Human  1255 DEDVQ-MERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGEV 1318

  Fly  1420 FGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKME-VGFCPQGDNAPKYLTGRQ 1483
            .||||..||||::..::|.|:|..:.|.:.::|..     ....:| :|:|||.:.....||.||
Human  1319 LGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSG-----GGDALEFLGYCPQENALWPNLTVRQ 1378

  Fly  1484 LLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALAI-DSGSVLCLDD 1547
            .|.::..:.|:.|...:....::......:|||..|:.|.|.|.||||...|:| .:.||:.||:
Human  1379 HLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSILGNPSVVLLDE 1443

  Fly  1548 TNGSVDHATQRFIWRKLEAV-KRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSE 1611
            .:..:|...|:.:|:.:.|. :.:.|..||||..|.||.|||.|||.:|:|.:..|||:|.::|:
Human  1444 PSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSK 1508

  Fly  1612 VSNTIVIRLRVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYHINI-NVTTLANLFYQM 1675
            .....::.::|     |...:.:.|.|::..|||.|...|...:.::|.:.: :|..||..|:::
Human  1509 FGKDYLLEMKV-----KNLAQVEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPLAQAFFKL 1568

  Fly  1676 EKIRNEGLLEDYSITQVSLDEIYRILNDEEDPNLVDLDSTHNSEV 1720
            ||::....||:||::|.:|::::..|:.|::  |.|.:...:..|
Human  1569 EKVKQSFDLEEYSLSQSTLEQVFLELSKEQE--LGDFEEDFDPSV 1611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_001262752.1	ABC2_membrane_3	32..>295	CDD:289468	61/307 (20%)
		ABC_subfamily_A	491..708	CDD:213230	73/222 (33%)
		drrA	498..796	CDD:130256	95/303 (31%)
		ABC2_membrane_3	<1132..1285	CDD:289468	31/160 (19%)
		CcmA	1391..1672	CDD:224054	91/295 (31%)
		ABC_subfamily_A	1391..1609	CDD:213230	77/231 (33%)
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324	158/597 (26%)
		ABC_subfamily_A	480..703	CDD:213230	73/222 (33%)
		rim_protein	<1033..1598	CDD:130324	146/601 (24%)
		ABC_subfamily_A	1285..1506	CDD:213230	76/225 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850