DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and ABCA9

DIOPT Version :10

Sequence 1:NP_732473.2 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:XP_024306297.1 Gene:ABCA9 / 10350 HGNCID:39 Length:1634 Species:Homo sapiens


Alignment Length:1833 Identity:432/1833 - (23%)
Similarity:783/1833 - (42%) Gaps:371/1833 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 WKDIKLQLTNWV-ELVMIIFLSALMPIFFSIGTKVAKSIFPPDIEMEKSPGPKSVNTSLFVDLYF 79
            |:..:..|..|: ..::::||.    :|||...:|..:   |.:.........|.|.:.:| :.|
Human    32 WRMKRQTLLEWLFSFLLVLFLY----LFFSNLHQVHDT---PQMSSMDLGRVDSFNDTNYV-IAF 88

  Fly    80 TPNNGILEQLITQLANISEFKSVEVF---DTNSELYLQLMINRNAIGIAFPSEW-YDIK------ 134
            .|.:...::::.::|:....|...:.   |..|...|.|..:.:|:.:.|...: |.:|      
Human    89 APESKTTQEIMNKVASAPFLKGRTIMGWPDEKSMDELDLNYSIDAVRVIFTDTFSYHLKFSWGHR 153

  Fly   135 ------------SCPEVLNLTIFMPLSIKRKDFKYFESGFLLLQERISKIFIFFKNAGNGKIPRV 187
                        .|..|..       .:|.:..:::|.||:..|..|:...|  :.|.|..:...
Human   154 IPMMKEHRDHSAHCQAVNE-------KMKCEGSEFWEKGFVAFQAAINAAII--EIATNHSVMEQ 209

  Fly   188 LMN----HFPYPSYVPNHYAESAKA---MTYMTLISFFLPCITIAKYV---VAEKERHQKAVLTA 242
            ||:    |.....:|    |:...|   ..:..:|||    .|...||   |.::.::..:::|.
Human   210 LMSVTGVHMKILPFV----AQGGVATDFFIFFCIISF----STFIYYVSVNVTQERQYITSLMTM 266

  Fly   243 MGFSNSIHWLAWYTKSMLLLLLCLLIMISIFSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISS 307
            ||...|..||:|.......:|:...:|..|.....|...:..|.:.|:||:|..||:..||.:|.
Human   267 MGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVMVFTLFLLYGLSLITLAFLMSV 331

  Fly   308 FFSRS-LSAVVATILMYFSTALPFLIVGAENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGA 371
            ...:. |:.:|..:|:.|...|.|   .|..:.:.|....::.|.|...:.:....::.:.    
Human   332 LIKKPFLTGLVVFLLIVFWGILGF---PALYTRLPAFLEWTLCLLSPFAFTVGMAQLIHLD---- 389

  Fly   372 QWYTIDNTA---SSGYKLSIVGYMLIMISISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWC 433
              |.:::.|   ||.....|:..:.:::..:.:.|::.||.:.:...|:            .:.|
Human   390 --YDVNSNAHLDSSQNPYLIIATLFMLVFDTLLYLVLTLYFDKILPAEY------------GHRC 440

  Fly   434 -PLRYGSSV--FHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRS 495
             ||.:..|.  |..|....:..:|...:.|..:...:|:            ......|..|.:::
Human   441 SPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPV------------SPEFCGKEAIRIKN 493

  Fly   496 LSKTFGFR----NVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVT 556
            |.|.:..:    ..:|.:.|::||.:||||:||.|:||||::.:|.|:..||:|:|.:..:.:..
Human   494 LKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTVYNHTLSR 558

  Fly   557 EAKVAKSS--LGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQKWDA 619
            .|.:...|  .|.|||.:|.|..::.::::..|:::||....|...|....:.:|.:.:.|...|
Human   559 MADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEMENIQDILA 623

  Fly   620 MRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLEEGE 684
            ..||.|..|:|:...|:....:|:|.|||::||||:.||.:...|::.|..|.||.:||.::|.:
Human   624 QNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFSTQFIDEAD 688

  Fly   685 ILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVFHGV 749
            |||||...:::|::.|.|:..:||:.....|.||..:......:::|.||:.:::..........
Human   689 ILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPESITSLVKQHISDAKLTAQSEE 753

  Fly   750 DVSYKLPRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGSSRLRGGADPGVN 814
            .:.|.||..:.::|||.::.|:..... .:..:|||.:||:.::|.|   :|.|.:         
Human   754 KLVYILPLERTNKFPELYRDLDRCSNQ-GIEDYGVSITTLNEVFLKL---EGKSTI--------- 805

  Fly   815 DKVEFGV----QTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKTPINPIEIWRPIDREKGSCM 875
            |:.:.|:    |||.|   ||  ..|||..:..:...:|    |:..|:.:.:|    |::...:
Human   806 DESDIGIWGQLQTDGA---KD--IGSLVELEQVLSSFHE----TRKTISGVALW----RQQVCAI 857

  Fly   876 AQWQAMFIKKKNYTASRALIFILILIIP-----LFYYIIVLGTAASEKCAHRTDKQPVLPLSLDY 935
            |:.:.:.:||:..:....|:...|..||     |||                ...|...|..|..
Human   858 AKVRFLKLKKERKSLWTILLLFGISFIPQLLEHLFY----------------ESYQKSYPWELSP 906

  Fly   936 YSYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPIIRRDIKRKYVCGASF 1000
            .:|             :.|.|    |..::|.|         |||    :|.:            
Human   907 NTY-------------FLSPG----QQPQDPLT---------HLL----VINK------------ 929

  Fly  1001 NNASTITAWFNSDAFEHSAPIALNLVYNALGKAVFEDQDFSILVNRGDLHDFIWLNNASSMRRRY 1065
             ..|||      |.|.||                ...|:.:|.|      |.....|.:      
Human   930 -TGSTI------DNFLHS----------------LRRQNIAIEV------DAFGTRNGT------ 959

  Fly  1066 KRQNDPDYT-------DYSDY---------EIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQM 1114
               :||.|.       |..|:         .:..:.|::...|:...|..|.|    ::|.|.:.
Human   960 ---DDPSYNGAIIVSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSS----EHIQTDRS 1017

  Fly  1115 SIIEAASTLYNEKGKRKQLFGTLII---ITAYIALCLSIFSIFVTKERVEHFKMQQEIYGVTLFY 1176
            :..|  ..:..|.|.|...|..:.:   .|.|||:.    ||...|::..   .|..|.|:....
Human  1018 TFFE--EHMDYEYGYRSNTFFWIPMAASFTPYIAMS----SIGDYKKKAH---SQLRISGLYPSA 1073

  Fly  1177 FWSTHFVGDFLIYAIYMGALTIAIYHFT---IWYQVVVMLLLIGFACLPFVYLCSLLFSLPNIAF 1238
            :|....:.|..:|.:.:..:.|..|.|:   |.:  ::..|||...| ...|:.||:|....|:|
Human  1074 YWFGQALVDVSLYFLILLLMQIMDYIFSPEEIIF--IIQNLLIQILC-SIGYVSSLVFLTYVISF 1135

  Fly  1239 AGIFAILVMTGGMLFSFMYMLTLI-----TDVNFTTVFAILPMYVGTFGLFKCLAWREYCNREVL 1298
              ||.......| ::||.:::.:|     ||:|   .:..|.::.||.               ::
Human  1136 --IFRNGRKNSG-IWSFFFLIVVIFSIVATDLN---EYGFLGLFFGTM---------------LI 1179

  Fly  1299 PPIEELDCKFGNCNVFCACKPERTWME---------VWL-LMVHCLVWFIFLWFSNFGYEIG--- 1350
            ||...:    |:..:|....|:.  |:         |:| |::..|.:.|||:.... .|:.   
Human  1180 PPFTLI----GSLFIFSEISPDS--MDYLGASESEIVYLALLIPYLHFLIFLFILRC-LEMNCRK 1237

  Fly  1351 --------YRFKPKLSNRIWHN------NEKHIRVLDEERRVGLIPKYEHEDYPIIVDQ-VTKNY 1400
                    :|..|: ||.|:.|      .|:.|: ::..|.|..:...:.::.|:|:.. :.|.|
Human  1238 KLMRKDPVFRISPR-SNAIFPNPEEPEGEEEDIQ-MERMRTVNAMAVRDFDETPVIIASCLRKEY 1300

  Fly  1401 C----------RAKNAVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYVRGHSL 1455
            .          :.|.|.:.|||.::.|:..||||..||||::..:||.|:|..:.|.:.::|...
Human  1301 AGKKKNCFSKRKKKIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGG 1365

  Fly  1456 REHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNFKDQLDRPI 1520
            .|....    :|:|||.:.....||.||.|.::..:.|:.|........::......:|||..|:
Human  1366 GEPLGF----LGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDALKLQDQLKAPV 1426

  Fly  1521 HTYSGGKKRKLNIALAI-DSGSVLCLDDTNGSVDHATQRFIWRKLEAV-KRSGRPVLLTTQSMEE 1583
            .|.|.|.||||...|:| .:.||:.||:.:..:|...|:.:|:.:.|. :.:.|..||||..|.|
Human  1427 KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAE 1491

  Fly  1584 ANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRVNPSDGKLKR--RFQQLIADMAELFPL 1646
            |.|||.|||.:|:|.:..|||:|.::|:.....::.:       |||.  :.:.|.|::..|||.
Human  1492 AEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEM-------KLKNLAQMEPLHAEILRLFPQ 1549

  Fly  1647 ATLHEALETCLIYHINI-NVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIYRILNDEE----- 1705
            |...|...:.::|.:.: :|..|:..|:::|.::....||:||::|.:|::::..|:.|:     
Human  1550 AAQQERFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDL 1614

  Fly  1706 ----DPNLVDLDS 1714
                ||:.:|.:|
Human  1615 EEDFDPSSLDCES 1627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_732473.2 rim_protein <118..1698 CDD:130324 405/1700 (24%)
ABCA9XP_024306297.1 ABC2_membrane_3 53..416 CDD:463674 80/396 (20%)
rim_protein <245..1609 CDD:130324 381/1575 (24%)

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