DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31213 and ABCA10

DIOPT Version :10

Sequence 1:NP_732473.2 Gene:CG31213 / 42382 FlyBaseID:FBgn0051213 Length:1809 Species:Drosophila melanogaster
Sequence 2:NP_525021.3 Gene:ABCA10 / 10349 HGNCID:30 Length:1543 Species:Homo sapiens


Alignment Length:1778 Identity:404/1778 - (22%)
Similarity:743/1778 - (41%) Gaps:380/1778 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 ITQLANISEFKSVEVFDTNSELYLQLMINR---NAIGIAFPSEW-YDIKSCPEVLNLTIFMPLSI 150
            :.::|..|..|...|..|..|..:.:.:.:   ..:|:.|...: |.:|     .|....:|:..
Human     1 MNKMALASFMKGRTVIGTPDEETMDIELPKKYHEMVGVIFSDTFSYRLK-----FNWGYRIPVIK 60

  Fly   151 KRKDF----------------KYFESGFLLLQERISKIFIFFKNAGNGKIPRVLMNH-------- 191
            :..::                ||:..||:..|..|           |..|..|..||        
Human    61 EHSEYTEHCWAMHGEIFCYLAKYWLKGFVAFQAAI-----------NAAIIEVTTNHSVMEELTS 114

  Fly   192 -----FPYPSYVPNHYAESAKAMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIHW 251
                 ...|.::..  .|......:.|.:..|...|..|...||.:....|.::|.||...|..|
Human   115 VIGINMKIPPFISK--GEIMNEWFHFTCLVSFSSFIYFASLNVARERGKFKKLMTVMGLRESAFW 177

  Fly   252 LAWYTKSMLLLLLCLLIMISIF------SIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFS 310
            |:|.     |..:|.:.::|||      ||.:::....:| :.|::.:|..||:..||.:|....
Human   178 LSWG-----LTYICFIFIMSIFMALVITSIPIVFHTGFMV-IFTLYSLYGLSLIALAFLMSVLIR 236

  Fly   311 RSLSAVVATILM-YFSTALPFLIVGAENSSVAAQTAASIGLNSALFYILDSVAVMEMQSVGAQWY 374
            :.:.|.:|..|. .|...|.|.:       :..|...|:|      ::|..::.....:..||..
Human   237 KPMLAGLAGFLFTVFWGCLGFTV-------LYRQLPLSLG------WVLSLLSPFAFTAGMAQIT 288

  Fly   375 TIDNTAS-------SGYKLSIVGYMLIMISISWIELLICLYIEAV---RTGEFEVPQPWSYPFQR 429
            .:||..|       ||....::....|:...:...|:..||.|.|   :.|..:.|   .:..:.
Human   289 HLDNYLSGVIFPDPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHGDSP---LFFLKS 350

  Fly   430 RYWCPLRYGSSVFHQGALLPLAGKNSEGNLPAAHPTRQPIIYLDDRTQENFQRVN--ISKKIGIE 492
            .:|..        ||.               ..|...:..|..:..:.::|:.|:  ...|..|.
Human   351 SFWSK--------HQN---------------THHEIFENEINPEHSSDDSFEPVSPEFHGKEAIR 392

  Fly   493 VRSLSKTF----GFRNVVKDLFFNVYENEITALVGHKGSGKTTIIMMLCGILQPTTGTVLINGYD 553
            :|::.|.:    |....::.:||::||.:|||::||.|:||:|::.:|.|:...|.|:..|....
Human   393 IRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQ 457

  Fly   554 I--VTEAKVAKSSLGICPQHSVIFKGMSARDHIYFFSRVKGYNKTEAMMESNIYISKLGLVDSQK 616
            :  :|:.:..:.::|.|||.:..|..::.|:::..|:::||....|...|....|.:|.:...|.
Human   458 LSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQEVKRIIMELDMQSIQD 522

  Fly   617 WDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGLDPIGRHELMRFLQKEKHGRTILMTTQQLE 681
            ..|.:||.|.:|:|:|..|:....:|:|.|||::||||..||.:...|::.|..|.||.:||.::
Human   523 IIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMD 587

  Fly   682 EGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTLSCQMAPNSKADNLTDLVRLYMTTTTSPVF 746
            |.:|||||...:::|::.|.|:..:||:.....|.||.........:.:|.|::.::........
Human   588 EADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTE 652

  Fly   747 HGVDVSYKLPRSQIDRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSLDYGQGSSRLRGGADP 811
            ....:.|.||..:.::||:.:..|::.... .:.::.||.::|:.::|:|   :|.|.:      
Human   653 SEEKLVYSLPLEKTNKFPDLYSDLDKCSDQ-GIRNYAVSVTSLNEVFLNL---EGKSAI------ 707

  Fly   812 GVNDKVEFGVQTDKAIR-TKDRANNSLVRYQHQVDPPNETIL----NTKTPINPIEIWRPIDREK 871
               |:.:|.:...:.|. |::..:.|.:          |.:|    .|:..::...:||      
Human   708 ---DEPDFDIGKQEKIHVTRNTGDESEM----------EQVLCSLPETRKAVSSAALWR------ 753

  Fly   872 GSCMAQWQAMFIKKKNYTASRALIFILILIIPLFYYIIVLGTAASEKCAHRTDKQPVLPLSLDYY 936
            ....|.....|:|.:.  ..|||:.:|          :|||.|             .:|:.|   
Human   754 RQIYAVATLRFLKLRR--ERRALLCLL----------LVLGIA-------------FIPIIL--- 790

  Fly   937 SYDDMIILLEVDKQLYKSEGEAYVQLVKEPATVESVDSIFSHLLKAPPIIRRDIKRKYVCGASFN 1001
                       :|.:||        :.:|....|...|::...|:..|                 
Human   791 -----------EKIMYK--------VTRETHCWEFSPSMYFLSLEQIP----------------- 819

  Fly  1002 NASTITAWFNSDAFEHSAPIALNLVYNALGKAVFED-------QDFSILVNRGDLHDFIWLNNAS 1059
                            ..|:...|:.|..|..: ||       ||..:     ::.||       
Human   820 ----------------KTPLTSLLIVNNTGSNI-EDLVHSLKCQDIVL-----EIDDF------- 855

  Fly  1060 SMRRRYKRQNDPDYT-------DYSDY---------EIQEYDVVVKPNSSSTSGQHN-------- 1100
               |.....:||.|.       |..||         ::..:.|::...|::..|..|        
Human   856 ---RNRNGSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQME 917

  Fly  1101 -KSNPGDDNIITVQMSIIEAASTLYNEKGKRKQLFGTLIIITAYIALCLSIFSIFVTKERVEHFK 1164
             .|...||  |.:.:..|:.:            :|  |::||..::..:.:.||...|:.|:   
Human   918 STSFSRDD--IVLDLGFIDGS------------IF--LLLITNCVSPFIGMSSISDYKKNVQ--- 963

  Fly  1165 MQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWYQV------VVMLLLIGFA-CLP 1222
            .|..|.|:....:|....:.|..:|.:.:.::.:..|...:.:|:      |:::.:||.| .|.
Human   964 SQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELMFVLVVCIIGCAVSLI 1028

  Fly  1223 FV-YLCSLLFS--LPNIAF--AGIFAILVMTGGMLFSFMY-MLTLITDVNFTTVFAILPMYVGTF 1281
            |: |:.|.:|.  ..|..|  .|.|.||:....::.|..| .|.||..:.|...|.:|       
Human  1029 FLTYVLSFIFRKWRKNNGFWSFGFFIILICVSTIMVSTQYEKLNLILCMIFIPSFTLL------- 1086

  Fly  1282 GLFKCLAWREYCNREVLPPIEELDCKFGNCNVFCACKPERTWME--VWLLMVHCLVWFIFLWFSN 1344
            |....|...::...     ::.||.:....|..........:::  ::|.::.||.       ..
Human  1087 GYVMLLIQLDFMRN-----LDSLDNRINEVNKTILLTTLIPYLQSVIFLFVIRCLE-------MK 1139

  Fly  1345 FGYEI-----GYRFKPKLSNRIWHNNEKHIRVLDEERRVGLI--------PKYEHEDYPIIVDQV 1396
            :|.||     .:|..|:  :|..|.|.:.....||:.:...:        |..|.|  |:|....
Human  1140 YGNEIMNKDPVFRISPR--SRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEE--PVITASC 1200

  Fly  1397 -------TKNYC----RAKNAVQLVSFAIRPGDTFGLLGAQGAGKTSIFQMIAGETSMSHGNIYV 1450
                   ||..|    :.|.|::.|||.::.|:..||||..||||::..:||.|.|..:.|.:.:
Human  1201 LHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVL 1265

  Fly  1451 RGH--SLR-EHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLLHGVPKDHIKAVSEQMAIEFNF 1512
            :|.  |:| :|.|:.|. :|:|||.::....||.::.|.::..:.|:.|:.......::......
Human  1266 QGSRASVRQQHDNSLKF-LGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKL 1329

  Fly  1513 KDQLDRPIHTYSGGKKRKLNIALAI-DSGSVLCLDDTNGSVDHATQRFIWRKLEA-VKRSGRPVL 1575
            ::||..|:.|.|.|.||||...|:| .:.||:.||:....:|...|:.:|:.|:| ||...|..|
Human  1330 QEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTL 1394

  Fly  1576 LTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRLRVNPSDGKLKRRFQQLIADM 1640
            |||..|.||.|||.|:|.:|:|.:..|||:|.::::.....::.:::     |...:.:.|..::
Human  1395 LTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKM-----KEPTQVEALHTEI 1454

  Fly  1641 AELFPLATLHEALETCLIYHINI-NVTTLANLFYQMEKIRNEGLLEDYSITQVSLDEIYRILNDE 1704
            .:|||.|...|...:.:.|.:.: :|..|:..|:::|.::....||:||::|.:|::::..|..|
Human  1455 LKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAMKQTFNLEEYSLSQATLEQVFLELCKE 1519

  Fly  1705 EDPNLVD--LDSTHNSEVL--ED 1723
            ::...||  :|:|...::|  ||
Human  1520 QELGNVDDKIDTTVEWKLLPQED 1542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31213NP_732473.2 rim_protein <118..1698 CDD:130324 389/1719 (23%)
ABCA10NP_525021.3 rim_protein <37..1520 CDD:130324 390/1718 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1177 6/25 (24%)

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