Protein Alignment CG31213 and ABCA7

DIOPT Version :10

• Sequence 1: NP_732473.2
• Gene: CG31213 / 42382
• FlyBaseID: FBgn0051213
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Alignment Length: 1790
• Identity: 453/1790 - (25%)
• Similarity: 753/1790 - (42%)
• Gaps: 383/1790 - (21%)

  Fly   147 PLSIKRKDFKYFESGFLLLQERISKIFIFFKNAGNGKIPR--VLMNHFPYPSYVPNHYAE--SAK 207
            ||:    |.:|...||:.||:.:.:..:...:..|   ||  :.:...|||.||.:.:..  |..
Human   492 PLT----DLRYVWGGFVYLQDLVERAAVRVLSGAN---PRAGLYLQQMPYPCYVDDVFLRVLSRS 549

  Fly   208 AMTYMTLISFFLPCITIAKYVVAEKERHQKAVLTAMGFSNSIHWLAWYTKSMLLLLLCLLIMISI 272
            ...::||...:...:|: |.||.|||...:..:.|||.|.::.||.|:...:...||...:::.:
Human   550 LPLFLTLAWIYSVTLTV-KAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLV 613

  Fly   273 FSIGLIYEFSSLVCLMTIFLVYIHSLVLFAFFISSFFSRSLSAVVATILMYFSTALPFLIVGAEN 337
            ..:|.|..:|....:......:..:.|..:|.:|:||||:..|.....|.|||..||:::..|..
Human   614 LKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWR 678

  Fly   338 SSVAA--QTAASIGLNSALFYILDSVAVMEMQSVGAQWYTIDNTASSG-YKLSIVGYMLIMIS-- 397
            ..:.|  :.|||:....|..:..:|:|::|.|..||||:.:....::. :.|:.|..:|::.:
Human   679 DRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAAL 743

  Fly   398 ---ISWIELLICLYIEAVRTGEFEVPQPWSYPFQRRYWCPLRYGSSVFHQGALLPLAGKNSEGNL 459
               .:|       |:|||..|::.:|:||::||:|.|||..|...|
Human   744 YGLATW-------YLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKS------------------- 782

  Fly   460 PAAHPTRQPIIYLDDRTQENFQRVNISKKIGIEVRSLSKTF--GFRNVVKDLFFNVYENEITALV 522
            ||..||.     ||.:.........:|.  |:.||||.|.|  ..:..::.|..:.|:..|||.:
Human   783 PAPCPTP-----LDPKVLVEEAPPGLSP--GVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFL 840

  Fly   523 GHKGSGKTTIIMMLCGILQPTTGTVLINGYDIVTEAKVAKSSLGICPQHSVIFKGMSARDHIYFF 587
            ||.|:||||.:.:|.|:..|:.|:..|.|:|:.:.....:..||:|||::|:|..::..:|::|:
Human   841 GHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFY 905

  Fly   588 SRVKGYNKTEAMMESNIYISKLGLVDSQKWDAMRLSPGNQRRLSLACALCAGSKVILCDEPSSGL 652
            .|:||.:......|.:..:..:|||..|......||.|.||:||:|.|...||:|::.|||::|:
Human   906 GRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGV 970

  Fly   653 DPIGRHELMRFLQKEKHGRTILMTTQQLEEGEILADRIAIMNDGQILCYGTLGYLKQLPFTSYTL 717
            ||..|..:...|.|.:.|||::::|..|:|.|:|.||:|::..|::.|.|:..:|::...:.|.|
Human   971 DPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYL 1035

  Fly   718 S-----CQMAPNSKADNLTDL----------------VRLYMTTTTSPVFH---GVDVSYKLPRS 758
            :     ..:..|.|||  ||:                .|:......:.|.|   |..:..:||..
Human  1036 TLVKARLPLTTNEKAD--TDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHE 1098

  Fly   759 QI----------DRFPEFFQQLEENKKSLNVVSFGVSDSTLDGIYLSL--------DYGQGS--S 803
            .:          ..|...|::|:.....|.:..:|:||::|:.|:|.:        |...||  .
Human  1099 LVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQ 1163

  Fly   804 RLRGGADPGVNDKVEFGVQTDKAIRTKDRANNSLVRYQHQVDPPNETILNTKTP----------- 857
            .|..|.           ...|..:|.|              .||.||.|....|
Human  1164 HLCTGI-----------AGLDVTLRLK--------------MPPQETALENGEPAGSAPETDQGS 1203

  Fly   858 ----INPIEIWRPIDREKGSCMAQWQAMFIKKKNYT-ASRALIFILILIIPLFYYIIVLGTAASE 917
                :..::.| .:.|:      |.||:.:|:.... .||..:|..|::..||..:.::.:....
Human  1204 GPDAVGRVQGW-ALTRQ------QLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVP 1261

  Fly   918 KCAHRTDKQPVLPLS-------LDYYSYD-----DMIILLEVDKQLYKSEGEAYVQLVKEPATVE 970
            ...|    .|.|.||       :.::|.|     ....|||.   |.:..|      ::||....
Human  1262 PFGH----YPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEA---LLQEAG------LEEPPVQH 1313

  Fly   971 SVDSIFSHLLKAPPIIRRDIKRKYVCGASFNNASTITAWFNSDAFEHSAPIALNL---------- 1025
            |     ||...||.:...  ..|.:...::...|.      |.|.:.|.|.|..|
Human  1314 S-----SHRFSAPEVPAE--VAKVLASGNWTPESP------SPACQCSRPGARRLLPDCPAAAGG 1365

  Fly  1026 -------------VYNALGKAVFEDQDFSI-----LVNRGDLHDFIWLNNASSMRRRY----KRQ 1068
                         |.|..|:.:   .||.:     ||.:| |....|:|..     ||    ...
Human  1366 PPPPQAVTGSGEVVQNLTGRNL---SDFLVKTYPRLVRQG-LKTKKWVNEV-----RYGGFSLGG 1421

  Fly  1069 NDPDYTDYSDY--EIQEYDVVVKPNSSSTSGQHNKSNPGDDNIITVQMSIIEAASTL---YNEKG 1128
            .||......:.  .::|...::.|.......:..|:       :|.....::|..:|   :|.||
Human  1422 RDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKN-------LTAWAHSLDAQDSLKIWFNNKG 1479

  Fly  1129 ----------------------------------------KRKQLF-GTLII--ITAYIALCL-- 1148
                                                    .::||. |.|:.  :...:::|:
Human  1480 WHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVF 1544

  Fly  1149 ------SIFSIFVTKERVEHFKMQQEIYGVTLFYFWSTHFVGDFLIYAIYMGALTIAIYHFTIWY 1207
                  :.|::.:.:|||...|..|.:.|::...:|..:|:.|...|.:   ...|.:..|..:.
Human  1545 AMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLV---PACIVVLIFLAFQ 1606

  Fly  1208 Q-----------VVVMLLLIGFACLPFVYLCSLLFSLPNIAFAGIFAILVMTG--GMLFSFMYML 1259
            |           ::::|||.|::..|.:|..|..||:|:.|:..:..|.:..|  |.:.:|  :|
Human  1607 QRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATF--VL 1669

  Fly  1260 TLITDVN-------FTTVFAILPMYVGTFGLFKCLAWREYCNREVLPPIEEL-DCKFGNCNVFCA 1316
            .|.:|..       ...||.|.|.:....||...:.     |:.:....|.| |.:|.:
Human  1670 ELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVR-----NQAMADAFERLGDRQFQS------ 1723

  Fly  1317 CKPERTWMEVWL-LMVHCLVWFIFLWFSNFGYEIGYRFKPKLSNRIWHNNEKHIRVLDEERRVGL 1380
              |.| |..|.. |:...:...:||.|:..               :.|.::     |..:.||..
Human  1724 --PLR-WEVVGKNLLAMVIQGPLFLLFTLL---------------LQHRSQ-----LLPQPRVRS 1765

  Fly  1381 IPKYEHEDYPI-----------------IVDQVTKNYCRAKN--AVQLVSFAIRPGDTFGLLGAQ 1426
            :|....||..:                 ::..:||.| |.:.  ||..:...|.||:.|||||..
Human  1766 LPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVY-RGQRMPAVDRLCLGIPPGECFGLLGVN 1829

  Fly  1427 GAGKTSIFQMIAGETSMSHGNIYVRGHSLREHRNAAKMEVGFCPQGDNAPKYLTGRQLLRIHCLL 1491
            ||||||.|:|:.|:|..|.|...:.|||:....:||.:.:|:|||.|...:.||||:.|.:...|
Human  1830 GAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARL 1894

  Fly  1492 HGVPKDHIKAVSEQMAIEFNFKDQLDRPIHTYSGGKKRKLNIALA-IDSGSVLCLDDTNGSVDHA 1555
            .|||:..:...:.............|||..|||||.||||..||| :...:|:.||:....:|.:
Human  1895 RGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPS 1959

  Fly  1556 TQRFIWRKLEAVKRSGRPVLLTTQSMEEANAVCSRVAFLVAGEMMFIGSLQQVRSEVSNTIVIRL 1620
            .:||:|..|.||.|.||.|:||:.||||..|:|||:|.:|.|....:||.|.::...:....:.|
Human  1960 ARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTL 2024

  Fly  1621 RVNPSDGKLKRRFQQLIADMAELFPLATLHEALETCLIYHINI-NVTTLANLFYQMEKIRNEGLL 1684
            ||..:      |.|...|.:|..||.|.|.||....|.:.:.. ....||.:|.::.....|..:
Human  2025 RVPAA------RSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGV 2083

  Fly  1685 EDYSITQVSLDEIYRILNDEEDPNLVDLDSTHNSE 1719
            ||:|::|..|:|::...:.::..   |.|:....|
Human  2084 EDFSVSQTMLEEVFLYFSKDQGK---DEDTEEQKE 2115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31213	NP_732473.2	rim_protein	<118..1698	CDD:130324	450/1767 (25%)
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	451/1782 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		3/15 (20%)