DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hs6st and hs6st1a

DIOPT Version :9

Sequence 1:	NP_001262750.1	Gene:	Hs6st / 42380	FlyBaseID:	FBgn0038755	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001018344.2	Gene:	hs6st1a / 553162	ZFINID:	ZDB-GENE-050524-1	Length:	405	Species:	Danio rerio

Alignment Length:	296	Identity:	164/296 - (55%)
Similarity:	219/296 - (73%)	Gaps:	4/296 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 FDMDGHDVMVFLHIQKTGGTSFGRHLVRDLDLKRPCECQRQRKRCYCFRPHRNENWLFSRYSTGW 205
            |::.|.||:|||||||||||:||||||:::.|:.||:|:..:|:|.|:||:|.|.|||||:||||
Zfish    72 FEIKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRKETWLFSRFSTGW 136

  Fly   206 KCGLHADWTELTSCVDVELDKNEGETA-KRRYFYISLLRQPIARYMSEYRHVRRGATWKGSRHWC 269
            .|||||||||||:||...|:|.|.... :|:::||:|||.|::||:||:|||:||||||.|.|.|
Zfish   137 SCGLHADWTELTNCVPGVLNKKESRMKNQRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMC 201

  Fly   270 LGRQATAAELPACYKGKDWLDVDLDQFAGCESNLAANRQTRMLADLALVGCYNKSSMPAHERDRV 334
            .||..|..|||.||:|.||....|.||..|..|||.|||.||||||:||||||.|.:|..:|.:|
Zfish   202 DGRTPTPEELPPCYEGTDWSGCTLQQFMDCPYNLANNRQVRMLADLSLVGCYNMSFIPEKKRAQV 266

  Fly   335 MLASAKRNLAAMAYFGLTEYQKMSQYIFEETFNLRFAIPFEQHNTTISATAVQNLRPDQKRRIEK 399
            :|.|||:||..||:|||||:|:.:||:||.||:|:|..||.|:|:|.:|..  :|..|..:|||:
Zfish   267 LLESAKKNLRDMAFFGLTEFQRKTQYLFERTFHLKFIRPFMQYNSTRAADV--DLDNDTIQRIEE 329

  Fly   400 LNSLDIELYAFAKTLLFQRFEHLKAKDTNFEQRYAN 435
            ||.||::||.:|:.|..||:.:.:..:.. |||..|
Zfish   330 LNDLDMQLYDYARDLFQQRYMYKRQLERR-EQRLKN 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hs6st	NP_001262750.1	Sulfotransfer_2	144..410	CDD:281554	155/266 (58%)
hs6st1a	NP_001018344.2	Sulfotransfer_2	76..340	CDD:281554	155/265 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595967
Domainoid	1	1.000	342	1.000	Domainoid score	I1043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75051
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2189
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1167623at2759
OrthoFinder	1	1.000	-	-		FOG0001176
OrthoInspector	1	1.000	-	-		otm25771
orthoMCL	1	0.900	-	-		OOG6_104471
Panther	1	1.100	-	-	O	PTHR12812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3281
SonicParanoid	1	1.000	-	-		X1002
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930