DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mira and SLMAP

DIOPT Version :9

Sequence 1:	NP_477291.1	Gene:	mira / 42379	FlyBaseID:	FBgn0021776	Length:	829	Species:	Drosophila melanogaster
Sequence 2:	NP_001364467.1	Gene:	SLMAP / 7871	HGNCID:	16643	Length:	852	Species:	Homo sapiens

Alignment Length:	784	Identity:	169/784 - (21%)
Similarity:	302/784 - (38%)	Gaps:	213/784 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LRLFRTPSLPQRLR----FRPTPSHTDTATGSGSGASTAASTPLHSAATTPVKEAKSASRLKGKE 149
            ::||....:..|||    ..|.||..|..                 ||.||...::...:|.
Human   125 IKLFLPDGMEARLRSDVIHAPLPSPVDKV-----------------AANTPSMYSQELFQLS--- 169

  Fly   150 ALQY--EIRHKNELIESQ----------------------------LSQLDVLRRHVD--QLKEA 182
              ||  |..|:.:::|.:                            ||:|:|:...:.  ...:.
Human   170 --QYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQT 232

  Fly   183 EAKLREEHELATSKTDRLIEALTSENLSHKALNEQMGQEHADLLERLAAMEQQLQQQHDE--HER 245
            |..||:| .:|..:.....|....|:|      .::.||..:::.:|:.:|:.|....||  |.:
Human   233 EDSLRKE-LIALQEDKHNYETTAKESL------RRVLQEKIEVVRKLSEVERSLSNTEDECTHLK 290

  Fly   246 QVEALVAESEALRLAN-------------ELLQTANEDRQKVEEQLQAQLSALQADVAQAREHCS 297
            ::.....| |...|||             :.|:.|...:::::::.||:...||..:.:..|...
Human   291 EMNERTQE-ELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQ 354

  Fly   298 LEQAKTAENIELVENLQK----TNASLLADVVQLKQQIEQDALSYGQEAKSCQAELECL--KVER 356
            ..|||       :|.||.    ||..|.|..|:| :.:::..|   :|..|...:::..  |:..
Human   355 ELQAK-------IEALQADNDFTNERLTALQVRL-EHLQEKTL---KECSSLGIQVDDFLPKING 408

  Fly   357 NTLKNDLANK----CTLIRSLQDELLDKNCEIDAHCDTIRQLCREQARHTEQQQAVAKVQQQVES 417
            :|.|..|.:|    ||.|....:  ..|...::.|...    ..|:.:.:::.|..||     ||
Human   409 STEKEHLLSKSGGDCTFIHQFIE--CQKKLIVEGHLTK----AVEETKLSKENQTRAK-----ES 462

  Fly   418 DLESAV--EREKS---YWRAELDKR---QKLAENELIKIELE--------KQDVMVLLETTNDML 466
            |....:  .:|||   ...|::|::   :.||:..|:|.:|:        ||::..|.:...:..
Human   463 DFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQ 527

  Fly   467 RMRDEKLQKC--------------EEQ---LRNGIDYYIQLSDALQQQLVQLKQDMAKTITEKYN 514
            .:.....|||              ||:   .||.::...:....||.||.:|..| .:.:.|:.:
Human   528 ELARTSKQKCFELQDTVFLLLALLEEERKAYRNQVEESTKQIQVLQAQLQRLHID-TENLREEKD 591

  Fly   515 YQLTLT----------------------NTRAT-VNILMERLKKSDADVEQYRAELESVQLAKGA 556
            .::|.|                      :.|.| :..|.|.|||..|::|::|......:....:
Human   592 SEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITS 656

  Fly   557 LEQSY-LVLQADAEQLRQQLTESQDALNALRSSSQTLQSEV-SLKESLLHELLAGEAETLAKFNQ 619
            |:.|: |..|...:|.|::.|..|..|..||.....|::|. |||..  :.||:.|.:...|  :
Human   657 LQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRE--NVLLSSELQRQEK--E 717

  Fly   620 IANSFQERIDGDAQLAHYHELRRKDETR----------------------EAYMVDMKKALDEFA 662
            :.||.::.::..:.|:.....|::.|.:                      |....|::|..::..
Human   718 LHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQ 782

  Fly   663 TVLQFAQLELDNKEQMLVKVREECEQLKLENIALKSK--------QPGSASL-------LGTPGK 712
            |||...:|:.:..||....:.:|.:|.|.....|:.|        .|..|:|       |..||.
Human   783 TVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPWPWMPMLAALVAVTAIVLYVPGL 847

  Fly   713 ANRS 716
            |..|
Human   848 ARAS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mira	NP_477291.1	SH3_and_anchor	<163..272	CDD:275056	28/153 (18%)
SLMAP	NP_001364467.1	FHA	14..108	CDD:238017
		SMC_prok_B	<163..819	CDD:274008	147/695 (21%)
		CC1_SLMAP	163..225	CDD:409287	10/66 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000