DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	529	Identity:	118/529 - (22%)
Similarity:	226/529 - (42%)	Gaps:	65/529 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GSFGRWQLRTILLIFLCKI----PSAWFTAI-IIYTAPYPWKGELVCHPADW----NVSRSQTEH 81
            |.|||:|::  |||.||.:    |..:|..: ::...|:.      |..| |    ..:.|..|.
Human    12 GDFGRFQIQ--LLILLCVLNFLSPFYFFAHVFMVLDEPHH------CAVA-WVKNHTFNLSAAEQ 67

  Fly    82 VDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVR---SHGQEWNASQSKEPGGQSSLPC---- 139
            :..:.||       |...:.:.|..:....|...::   ||  .:|.:|          ||
Human    68 LVLSVPL-------DTAGHPEPCLMFRPPPANASLQDILSH--RFNETQ----------PCDMGW 113

  Fly   140 EHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQI 204
            |:.|:|  ..||.::|:|:|.|:.|...|||....|.|:|.||......:|..:..:|..::...
Human   114 EYPENR--LPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFT 176

  Fly   205 FCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELFWSMGLVLLP 269
            ..|..|..|.:::|::..|...:...|.:..|...:|.:......|...|.|::..:|:|.::|.
Human   177 LIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLA 241

  Fly   270 AISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYNNRKVPLTL 334
            .::..|.||..|.:..::..::|.:....:.::.||||...|::.|::.:.::|:.|.||:...|
Human   242 GLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPEL 306

  Fly   335 DVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMIRNLGAQQVHV 399
            ..||      :.:|:....:...::.....|...:.|..:|....:.|..:.|.:.:.|. .|::
Human   307 MNQL------VPEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGL-DVYL 364

  Fly   400 NTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSRRVGLELVFWL 464
            .....|..|:......::::....|.|...|.| ::.||...:|..:|        ..|.:|..:
Human   365 TQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTL-VLGGLMCIIIIFIP--------ADLPVVVTM 420

  Fly   465 IL---KIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPFLSCLTVIHHLVPITIL 526
            :.   |:|.:|:..:....::|:.....|...|..|..|||:..:..|.:..|...|..:|:.|.
Human   421 LAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIY 485

  Fly   527 ATMGWIYGL 535
            .::..:.||
Human   486 GSLPIVAGL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	118/529 (22%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	80/375 (21%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	118/529 (22%)
		MFS	139..500	CDD:119392	79/372 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850