Protein Alignment CG4459 and SLC22A14

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 126/554 - (22%)
• Similarity: 218/554 - (39%)
• Gaps: 113/554 - (20%)

  Fly    18 LDVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAI--IIYTAPYPWKGELVCHPADWNVSRSQTE 80
            ||.|    |.||.:|.|.:.|.|:..|.||:|...  .::||..|:     |: ..|.::..  .
Human   137 LDAV----GEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPY-----CN-TSWILAVG--P 189

  Fly    81 HVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEHVEHR 145
            |:.:...|           |:.:..|.:.|....|:.. ...||.....:.|...:..|:.....
Human   190 HLSKAEQL-----------NLTIPQAPNGSFLTCFMYL-PVPWNLDSIIQFGLNDTDTCQDGWIY 242

  Fly   146 TDYK--SLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQIFCGN 208
            .|.|  |||::|||:|.........|.....|..||.|:......|:.....:||.::|.|..|.
Human   243 PDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSLLGLIIFGF 307

  Fly   209 LTGLVDTYQLHIYFR----------CLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELFWSM 263
            .|..::::.|:::||          .::||..|..:..|:.          |...:.|...|:::
Human   308 GTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEH----------RAHAIILGHCFFAV 362

  Fly   264 GLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWI-ADAPRWLLQHQRVEAALRQLLESATYNN 327
            |.|||..|:....:|..|:: :...|::....:.|| .::||||:...:|:.|.:.|..:|:.|.
Human   363 GAVLLTGIAYSLPHWQLLFL-VGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNK 426

  Fly   328 RKVPLTLDVQLTMYANDLD--QKSKQKHSYCQVWDGETKRSQLVYIHL----IWGGAMVLYNIIL 386
            :.:|          :|.||  |..::|.:...|.| ..|..||..:.|    :|......|..:.
Human   427 KTIP----------SNLLDELQLPRKKVTRASVLD-FCKNRQLCKVTLVMSCVWFTVSYTYFTLS 480

  Fly   387 LMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLL----- 446
            |.:|.||. .||.........|:......::|:....|.|..|..|:      ..:||.|
Human   481 LRMRELGV-SVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLL------QAIIWCLLLLFL 538

  Fly   447 --------------PETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKR------- 490
                          |.||..|    :.::..::.:.:.:|::.|....|:|::....|
Human   539 PEGEDGLRLKWPRCPATELKS----MTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLV 599

  Fly   491 -------VVLMLSVISFSRVCLLFCPFLSCLTVI 517
                   .:|.|::|  |:...|...||.|:..|
Human   600 SLASVAGAILSLTII--SQTPSLLPIFLCCVLAI 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	123/546 (23%)
		MFS	164..540	CDD:119392	88/404 (22%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	123/546 (23%)
		MFS	270..641	CDD:119392	87/397 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850