DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	546	Identity:	117/546 - (21%)
Similarity:	226/546 - (41%)	Gaps:	89/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCH-PADWNVSRSQTEHV 82
            |:::|| |..||:|...:.|:.|..:..|....:..:||..|...   |. |||.|:|::....|
Human     5 DLLQQV-GGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH---CRPPADANLSKNGGLEV 65

  Fly    83 DRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEH---VEH 144
                  |   ...||....:.|..:: |...|....:|.|.|.:.:.|       ||..   .::
Human    66 ------W---LPRDRQGQPESCLRFT-SPQWGLPFLNGTEANGTGATE-------PCTDGWIYDN 113

  Fly   145 RTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQIFCGNL 209
            .|...::::::||:||.|.|..|.||.:.:|.|:|.::......::..|::::|..:.....|..
Human   114 STFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTC 178

  Fly   210 TGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSG------KARIIVVTLSELFWSMGLVLL 268
            ......:.::..||.|:.:  ||...|    ||.:|..      ..|..|.||....:|:|..||
Human   179 AAFAPNFPIYCAFRLLSGM--ALAGIS----LNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLL 237

  Fly   269 PAISIYFDNWSYLYVAISSSLIVLVWLHRW-IADAPRWLLQHQRVEAALRQLLESATYNNRK--- 329
            ..::....:|.:|.:.:|:..... :::.| ..::.||.....|::..||.|...|..|.::
Human   238 AGVAYAVPHWRHLQLLVSAPFFAF-FIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEG 301

  Fly   330 VPLTLDV-------QLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILL 387
            ..|:::|       :|||        .|.:.|..::....|.|...:.:.::|......|..:::
Human   302 AKLSMEVLRASLQKELTM--------GKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVM 358

  Fly   388 MIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYT--RRHWRWAGNLMIIAGLSTYLIWLLPETE 450
            .::..|. .:::.....|..::....|| :|::.:  ||..:.|.  :::||:...|..::|:.:
Human   359 DLQGFGV-SIYLIQVIFGAVDLPAKLVG-FLVINSLGRRPAQMAA--LLLAGICILLNGVIPQDQ 419

  Fly   451 ---RNSRRVGLELVFWLILKIANSASIAVLTTC----TSEIVSKEKRVVLMLSVISFSRVCLLFC 508
               |.|            |.:.....:|....|    |.|:.....|...|....:.:||..:..
Human   420 SIVRTS------------LAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVS 472

  Fly   509 PFLSCLTVIHHLVPITILATMGWIYG 534
            |.:|....::..:|:       :|||
Human   473 PLVSMTAELYPSMPL-------FIYG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	114/539 (21%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	79/397 (20%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	114/539 (21%)
		MFS	135..505	CDD:119392	78/395 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840