DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and slc22a21

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001295487.1	Gene:	slc22a21 / 799908	ZFINID:	ZDB-GENE-091118-62	Length:	546	Species:	Danio rerio

Alignment Length:	574	Identity:	135/574 - (23%)
Similarity:	233/574 - (40%)	Gaps:	66/574 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVVEQVN--GSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCH----PADWNVSRS 77
            |..||..  |::|.:|.....|:.|..||:. ||.:.|.     :.|:...|    |...|::..
Zfish     5 DYEEQTAFLGAWGPFQKTVFSLLCLSIIPNG-FTGLSIV-----FLGDTPAHHCRIPETLNLTAG 63

  Fly    78 -QTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEH 141
             :...|.|..|......|......:|:...||:.   |.:  .|.:.|.|:         :|.|.
Zfish    64 WRNASVPRPQPHGDPRASRCYRLRLDLVKNYSDG---GLL--PGLDVNVSE---------IPREE 114

  Fly   142 -----VEHRTDYKS-LISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGM 200
                 :..:..|.| ::|::||:||......||.|....|.|.|.:::.....:...:.::.:.|
Zfish   115 CADGWIYDKEIYSSTIVSEWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTM 179

  Fly   201 IGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQ---------FILN-DITSGKARIIVVT 255
            ..|.       |....|:   |.....|||.|.:..|.         |:|. :|.|...|.:..|
Zfish   180 AIQT-------LFTVVQV---FSPSWQIFCFLFFIVGMGQISNYVAAFVLGMEILSSSVRDVYST 234

  Fly   256 LSE-LFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQL 319
            |.. ||:|:|.::||..:.:..:|..|.:|::......:.|..:|.::|||||...||:.|...:
Zfish   235 LGVCLFFSIGYMILPLAAFFLRDWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAII 299

  Fly   320 LESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNI 384
            .::|..|....|   ||...:..:..|....|..|.|::......|.....:.|||....:.|..
Zfish   300 RKAAKINRVTAP---DVIFPLMQSTEDAGGVQSFSVCELLKSSNIRYMTGLLCLIWMAVSIGYCA 361

  Fly   385 ILLMIRNLGAQQVHVNTAAMGFAEMVGLFVG-LYLILYTRRHWRWAGNLMIIAGLSTYLIWLLPE 448
            :.|...:|.. .:::|.......|:..|.:. |.|.|..|||  ...:.:.:.||...||.|:||
Zfish   362 LSLNTSSLHG-NIYLNCLLSAVVEVPALLMAWLMLRLAPRRH--CLASTLALGGLVLLLILLIPE 423

  Fly   449 TERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPFLSC 513
            .:.:   |.|.||  ::.|...||:.:::...|:|:.....|...:.:....|||..:..|:.:.
Zfish   424 DQSS---VTLALV--MLGKFGLSAAFSIIYPVTAELYPTVLRNTALGACSMSSRVGGISAPYFNY 483

  Fly   514 LTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNTYRRQSAI 567
            |...|..:|..::..:..:.||....|.....:.....|.|:.|....::.|.:
Zfish   484 LGSYHRSLPYILIGGINVLSGLLSFLLPESRGSALPETIGQMQTVKGLKKHSPL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	126/532 (24%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	93/387 (24%)
slc22a21	NP_001295487.1	2A0119	14..521	CDD:273328	128/547 (23%)
slc22a21	NP_001295487.1	MFS	146..511	CDD:119392	93/385 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840