DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4459 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus

Alignment Length:	475	Identity:	96/475 - (20%)
Similarity:	183/475 - (38%)	Gaps:	83/475 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DVCNAYSNSLARGFVRSHGQEWNASQSKE-------PG-GQSSLPCEHVEHRTDY-------KSL 151
            |:.|..|.|.......|.|...|.|.|.:       || |.:...|:.  |..||       :::
Mouse   148 DMGNWTSPSATPFSTASWGTTSNRSNSSDTPPLPSPPGKGNNDSNCDC--HAWDYGIRTGLIQNV 210

  Fly   152 ISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQIFCGNLTGL---V 213
            :|::||:|.....|.:.:....:|.:.|.|:.......:..|.::|...|..:..|....|   |
Mouse   211 VSKWDLVCDNTWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSTIFILIFGLTVALSVNV 275

  Fly   214 DTYQLHIYFR--CLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELFWSM-GLVLLPAISIYF 275
            ..:....:|.  ||..|...|      :.|........:..::|:...|.:| |..|:|.::...
Mouse   276 TMFSTLRFFEGFCLAGIILTL------YALRIELCPPGKRFIITMVASFVAMAGQFLMPGLAALC 334

  Fly   276 DNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYNNRKVPLTLDVQLTM 340
            .:|..|...|....::::.......::.|||:..|:.|:|.:.:|    |..:|..::.:..:..
Mouse   335 RDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLIL----YLTQKNCVSPESDIKG 395

  Fly   341 YANDLDQK-SKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMIRNLGAQQVH--VNTA 402
            ...:|::: |::....|.|        ::|....:|      .||::|.:.:|....:|  ...:
Mouse   396 VMPELEKELSRRPKKVCIV--------KVVGTRNLW------KNIVVLCVNSLTGYGIHHCFARS 446

  Fly   403 AMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILK 467
            .||....|.|....|...||      ..::.:.:.|:..|:     .:...||.|| |:|.::..
Mouse   447 MMGHEVKVPLLENFYADYYT------MASIALASCLAMCLV-----VKFLGRRGGL-LLFMILTA 499

  Fly   468 IANSASIAVLTTCTSEIVSKEKRVVLMLSV-----------ISFSRVCLLFCPFLSCLTVIH--H 519
            :|:...:.:|..........:..:.|.|:|           |:||.|.:.....:..|:|..  .
Mouse   500 LASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAE 564

  Fly   520 LVPITI--------LATMGW 531
            :.|..|        ||:.|:
Mouse   565 ITPTVIRCGGLGLVLASAGF 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	96/475 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	76/398 (19%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		2A0119	98..631	CDD:273328	96/475 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		7/25 (28%)
		MFS	230..>359	CDD:119392	24/134 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930