DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4459 and Slc22a16

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_081848.1	Gene:	Slc22a16 / 70840	MGIID:	1918090	Length:	649	Species:	Mus musculus

Alignment Length:	664	Identity:	127/664 - (19%)
Similarity:	248/664 - (37%)	Gaps:	157/664 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GSFGRWQLRTILLIFLCKIPSA-----WFTAIIIYTAPYPWKGELVCHP------------ADWN 73
            |.|||:|   |:|..:|...|.     :.:::.:...|     |..|.|            :.|.
Mouse    14 GHFGRFQ---IVLYLICAYQSLSCGIHYLSSVFLSIIP-----EHACKPPGMVRKAVFHNVSAWR 70

  Fly    74 VS-----RSQTEHVD------RNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSH-GQEWNAS 126
            :.     || .||.|      ::..:|:..|.: |.:..:.              || |.|::
Mouse    71 LEDILALRS-PEHKDHIMVELQDGEIWELTRCS-RTWRENT--------------SHLGYEYS-- 117

  Fly   127 QSKEPGGQSSLPC--EHVEHRTDYK-SLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALK 188
                 |.:...||  .:|..::.:: |.:..|:|:|.::....:.|.....|.::|.: .:|.|.
Mouse   118 -----GYKHDSPCFDGYVYDQSKWRNSAVRNFNLVCDQKWYARMIQPLIIFGVMLGSI-TFSYLS 176

  Fly   189 KISPRRLML-LGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFI-----LNDITSG 247
            ....||:.| ...||..|.|     :.:..:..|...:.:.|..:|.:||.|:     :.:|...
Mouse   177 DRFGRRMALWCTSIGVFFFG-----IASLFIFDYLSFMITRFFLVMASSGYFVVVFVYVMEIIGK 236

  Fly   248 KARIIVVTLSELFWSMGLVLLPAISIYFDNWSYLY----VAISSSLIVLVWLHRWIADAPRWLLQ 308
            |||.........|:::|.:|:...|.....| :||    ..:::..|:..|:   :.:.|.|||.
Mouse   237 KARTWASIHLNTFFAIGAMLVALASYLLKTW-WLYQIILCIVTTPFILCCWM---LPETPFWLLS 297

  Fly   309 HQRVEAALRQLLESATYNNRK-----VPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQL 368
            ..|.:.|...:...|.:|...     ..|:|||   ..:::....|.:||....::.........
Mouse   298 EGRYKEAQGTVDTMAVWNKSSSCDLVELLSLDV---TRSHNKSPHSIRKHRLADLFHNLDVAKMT 359

  Fly   369 VYIHLIWGGAMVLY--------------NIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLI 419
            :.:.|.|..|.:.|              .:.||::   ||.::........:.:.||....:.|.
Mouse   360 LIVWLDWFTANLGYYMFGKEVIRRKENEPLYLLLV---GAMEIPAYICLCIWLKRVGRRKTMLLF 421

  Fly   420 LYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEI 484
            |             :::.|:..|..::|...:.::|     :..|::|...|:..|.:...|:|:
Mouse   422 L-------------LVSSLTCMLHVVMPSDYKTAKR-----MVALLVKSVISSVFAFIYLYTAEL 468

  Fly   485 VSKEKRVVLMLSVISFSRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQ 549
            .....|.:.:.|....|.|..:|.||.|..:.:...:|..:...:..:.||...:|
Mouse   469 YPTTVRCLAVGSSNMVSHVSSIFIPFTSHFSKVWIFLPQILFGILAILSGLLSLKL--------- 524

  Fly   550 PQISQVPTPNTYRRQSAIILRRCSTVSSDCSAYSNELLSNFER---NMAVSIADIWHINFHPSSE 611
            |:....|..:|:....       ..|..:..:.......:|||   :.|:|.|:.|.::
Mouse   525 PETQDTPMKSTWETTE-------QQVPENKDSLGEGPPDSFERWDSSRALSFAERWGLS------ 576

  Fly   612 IEMEVEQSGPEAHR 625
                  ::.|:|.:
Mouse   577 ------RASPDAEK 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	112/570 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	79/404 (20%)
Slc22a16	NP_081848.1	2A0119	14..535	CDD:273328	116/594 (20%)
		MFS	163..525	CDD:119392	79/404 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..560		4/36 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..649		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030