DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and SLC22A5

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens

Alignment Length:	585	Identity:	122/585 - (20%)
Similarity:	228/585 - (38%)	Gaps:	91/585 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EQVNGSFGRWQLRTILLIFLCK---IPSAW--FTAIIIYTAPYPWKGELVCH-PADWNVSRSQTE 80
            ::|....|.|.....|:.||..   ||:.:  .:::.:...|     |..|. |...|:|.:.
Human     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATP-----EHRCRVPDAANLSSAW-- 62

  Fly    81 HVDRNH--PL-WQDAR----STDRLFNVDVCNAYSNSLARGFVRSHGQ--------EWNASQ--- 127
               |||  || .:|.|    |..|.....:.|..:..|..|.....||        .|..||
Human    63 ---RNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVY 124

  Fly   128 ------SKEPGGQSSLPCEHVEHRTDYK---SLISQFDLICSRRVLVALTQSFHALGALIGGLMA 183
                  .::.|..:::     ::|...|   .|.:|::|:|.......||.|...:|.|:|..::
Human   125 LSTIVTEQDSGAYNAM-----KNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFIS 184

  Fly   184 YSALKKISPRRLMLLGM-------IGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFIL 241
            .....:...:.::.:.|       ..|||..|       :::.:....|..:.....|.:. |:|
Human   185 GQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKN-------FEMFVVLFVLVGMGQISNYVAA-FVL 241

  Fly   242 NDITSGKA-RIIVVTLSE-LFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPR 304
            .....||: |||..||.. :|::.|.::||..:.:..:|..|.||::...::.|.|..:|.::||
Human   242 GTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPR 306

  Fly   305 WLLQHQRVEAALRQLLESATYNNRKVPLTL----DVQLTMYANDLDQKSKQKHSYCQVWDGETKR 365
            ||:...|.|.|...:.::|..|...||.|:    ::|      ||..|.:|.|:...:......|
Human   307 WLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQ------DLSSKKQQSHNILDLLRTWNIR 365

  Fly   366 SQLVYIHLIWGGAMVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAG 430
            ...:...::|....|.|..:.|...||.. .:.||.......|:....:...|:.|..|.:..|.
Human   366 MVTIMSIMLWMTISVGYFGLSLDTPNLHG-DIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMAT 429

  Fly   431 NLMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLML 495
            .|.:...:..::..:.|:.      ..|..|..::.|...:|:.:::...|:|:.....|.:.:.
Human   430 ALFLGGSVLLFMQLVPPDL------YYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVG 488

  Fly   496 SVISFSRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT 560
            ...:.||:..:..|:...|......:|..::.::..:..:....|         |:....|.|:|
Human   489 VSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFL---------PESFGTPLPDT 544

Fly 561 560
Human 545 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	116/555 (21%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	79/388 (20%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	120/576 (21%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	80/401 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840