Protein Alignment CG4459 and SLC22A4

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 121/591 - (20%)
• Similarity: 239/591 - (40%)
• Gaps: 108/591 - (18%)

  Fly    17 ELDVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCH-PADWNVSRSQTE 80
            :.|.|....|.:|.:|.....|:....||:.:....:::.|..|   |..|. |...|:|.:.
Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTP---EHRCRVPDAANLSSAW-- 62

  Fly    81 HVDRNH--PL-WQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEHV 142
               ||:  || .:|.|....     .|:.|..:....|         ::...|||....|.....
Human    63 ---RNNSVPLRLRDGREVPH-----SCSRYRLATIANF---------SALGLEPGRDVDLGQLEQ 110

  Fly   143 EHRTD---------YKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLL 198
            |...|         ..:::::::|:|.....|.||.|...:|.|:|..::.....:...:.::..
Human   111 ESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFA 175

  Fly   199 GMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQ-------FILNDITSGKA-RIIVVT 255
            .|..|      ||........|.:...|.:|  ::...||       |||.....||: |||..|
Human   176 TMAVQ------TGFSFLQIFSISWEMFTVLF--VIVGMGQISNYVVAFILGTEILGKSVRIIFST 232

  Fly   256 LSE-LFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQL 319
            |.. .|:::|.:|||..:.:..:|..|.:|::...::.|.|..:|.::||||:..:|...|...:
Human   233 LGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDII 297

  Fly   320 LESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNI 384
            .::|..||..||..:...:    .:|:...:||.....::     |::.:.|       |.:.::
Human   298 QKAAKMNNIAVPAVIFDSV----EELNPLKQQKAFILDLF-----RTRNIAI-------MTIMSL 346

  Fly   385 ILLMIRNLG-------AQQVH----VNTAAMGFAEMVGLFVGLYLILYT--RRH-----WRWAGN 431
            :|.|:.::|       |..:|    :|.......| :..::..:|:|.|  ||:     ..|.|.
Human   347 LLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIE-IPAYITAWLLLRTLPRRYIIAAVLFWGGG 410

  Fly   432 LMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLS 496
            :::       .|.|:| .:.....:||.    ::.|...:::.::|...|:|:.....|.:.:..
Human   411 VLL-------FIQLVP-VDYYFLSIGLV----MLGKFGITSAFSMLYVFTAELYPTLVRNMAVGV 463

  Fly   497 VISFSRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNTY 561
            ..:.|||..:..|:...|...:.::|..::.::..:.|:    |..::     |:...:..|.|.
Human   464 TSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGI----LTLFF-----PESLGMTLPETL 519

  Fly   562 RRQSAI 567
            .:...:
Human   520 EQMQKV 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	115/549 (21%)
		MFS	164..540	CDD:119392	85/402 (21%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	118/573 (21%)
		MFS	123..508	CDD:119392	88/430 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840