Protein Alignment CG4459 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 123/591 - (20%)
• Similarity: 227/591 - (38%)
• Gaps: 110/591 - (18%)

  Fly    16 PELDVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYP------------------WK 62
            |..|...|..|.|||:|.|..||:.|..:..|:....:::....|                  |.
Human     2 PSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWS 66

  Fly    63 GELVCHPADWN----VSRSQTEHVDRN--------HPLWQDARSTDRLFNVDVCNAYSNSLA--- 112
            .|     .:||    .||. .|..:|.        ......|.:|..|...|...|:.|..|
Human    67 PE-----EEWNRTAPASRG-PEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLV 125

  Fly   113 --RGFVRSHGQEWNASQSKEPGGQSSLPCEHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALG 175
              ||       .|..:|:                   :.:::|:|||:|....::.|||:...||
Human   126 PCRG-------GWRYAQA-------------------HSTIVSEFDLVCVNAWMLDLTQAILNLG 164

  Fly   176 ALIGGLMAYSALKKISPRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFI 240
            .|.|......|..:.....:.||..:|....|.:......:.:.:.||.|..:|....:.:...|
Human   165 FLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVI 229

  Fly   241 LNDITSGKARIIVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAIS-SSLIVLVWLHRWIA-DAP 303
            :.:|...|.|.||..:.::|:::|:::||.|:.:..||..:.:||: .|.:.|  |:.|:. ::|
Human   230 VTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFL--LYYWVVPESP 292

  Fly   304 RWLLQHQRVEAALRQLLESATYNNRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQL 368
            |||:..::.:.||:.|...|..|.:.:..... ::|:...::...     |:..:......|...
Human   293 RWLITRKKGDKALQILRRIAKCNGKYLSSNYS-EITVTDEEVSNP-----SFLDLVRTPQMRKCT 351

  Fly   369 VYIHLIWGGAMVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLM 433
            :.:...|..:.|:|..:::.:..:|. .::::....|..|:.|..:.|..|....|...:|.: .
Human   352 LILMFAWFTSAVVYQGLVMRLGIIGG-NLYIDFFISGVVELPGALLILLTIERLGRRLPFAAS-N 414

  Fly   434 IIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVI 498
            |:||::..:...|||.           :.||...:|....:.:  |...|||......:...::.
Human   415 IVAGVACLVTAFLPEG-----------IAWLRTTVATLGRLGI--TMAFEIVYLVNSELYPTTLR 466

  Fly   499 SFS-RVCLLFCPF--------LSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQ 554
            :|. .:|...|.|        |..|..:...:|:.|...:..|.|..:..|         |:...
Human   467 NFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLL---------PETKG 522

  Fly   555 VPTPNT 560
            :..|.|
Human   523 IALPET 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	116/555 (21%)
		MFS	164..540	CDD:119392	81/386 (21%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	119/579 (21%)
		MFS	149..518	CDD:119392	82/400 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840