DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4459 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_072146.1	Gene:	Slc22a23 / 64559	RGDID:	620302	Length:	689	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	112/556 - (20%)
Similarity:	205/556 - (36%)	Gaps:	110/556 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GSFGRWQLRTILLIFLCKIPSAW-----FTAIIIYTAPYPWKGELVCHPADWNVSRSQTEHVDRN 85
            |..|....:|  |:.|..||:.:     |:...:...|..|     ||.|......:......|
  Rat    89 GGLGGGYQKT--LVVLTWIPALFIGFSQFSDSFLLDQPNFW-----CHGAGKGTELAGATVTGR- 145

  Fly    86 HPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKE-------PG-GQSSLPCEHV 142
               |.           |:.|..|.|.......|.|...|.|.|.:       || |.:...||.
  Rat   146 ---WG-----------DMGNWTSPSATPFSTASWGTTSNRSNSSDTPPLPSPPGKGNNDSNCEC- 195

  Fly   143 EHRTDY-------KSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGM 200
             |..||       ::::|::||:|.....|.:.:....:|.:.|.|:.......:..|.::|..:
  Rat   196 -HAWDYGIRTGLVQNVVSKWDLVCDNAWKVHVAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSV 259

  Fly   201 IGQIFCGNLTGL---VDTYQLHIYFR--CLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELF 260
            |..:..|....|   |..:....:|.  ||..|...|      :.|........:..::|:...|
  Rat   260 IFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTL------YALRIELCPPGKRFIITMVASF 318

  Fly   261 WSM-GLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESAT 324
            .:| |..|:|.::....:|..|...|....::::.......::.|||:..|:.|:|.:.:|
  Rat   319 VAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLIL---- 379

  Fly   325 YNNRKVPLTLDVQLTMYANDLDQK-SKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLM 388
            |..:|..::.:..:.....:|::: |::....|.|        ::|....:|      .||::|.
  Rat   380 YLTQKNCVSPESDIKGVMPELEKELSRRPKKVCIV--------KVVGTRNLW------KNIVVLC 430

  Fly   389 IRNLGAQQVH--VNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLPETER 451
            :.:|....:|  ...:.||....|.|....|...||      ..::.:.:.|:..|:     ...
  Rat   431 VNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYT------MASIALASCLAMCLV-----VRF 484

  Fly   452 NSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSV-----------ISFSRVCL 505
            ..||.|| |:|.::..:|:...:.:|..........:..:.|.|:|           |:||.|.:
  Rat   485 LGRRGGL-LLFMILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFSIAFSIVGM 548

  Fly   506 LFCPFLSCLTVIH--HLVPITI--------LATMGW 531
            .....:..|:|..  .:.|..|        ||:.|:
  Rat   549 FASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	112/556 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	76/398 (19%)
Slc22a23	NP_072146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		7/25 (28%)
		MFS_SLC22A23	187..608	CDD:341002	86/436 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930