DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4459 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	569	Identity:	116/569 - (20%)
Similarity:	221/569 - (38%)	Gaps:	80/569 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EQVNGSFGRWQLRTILLIFLCK---IPSAW--FTAIIIYTAPYPWKGELVCH-PADWNVSRSQTE 80
            ::|....|.|.....|:.||..   ||:.:  .:|:.:...|     |..|. |...|:|.:.
Mouse     5 DEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIP-----EHRCRIPDTVNLSSAW-- 62

  Fly    81 HVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEHVEHR 145
               |||.:..:.:....:  ...|..|..:....|         :....|||....|  |.:|..
Mouse    63 ---RNHSIPMETKDGPEV--PQKCRRYRLATIANF---------SELGLEPGRDVDL--EQLEQE 111

  Fly   146 T-----DY------KSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLG 199
            .     :|      .::::::||:|.......||.||..:|.|:|..::.....:...:.::.|.
Mouse   112 NCLDGWEYDKDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLT 176

  Fly   200 MIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYT----------SGQFIL-NDITSGKARIIV 253
            |...      ||........:.|...|     |:||          ...|:| .::.|...|||.
Mouse   177 MAMH------TGFSFIQVFSVNFEMFT-----LLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIF 230

  Fly   254 VTLSE-LFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALR 317
            .||.. :|::.|.::||..:.:...|..|.:||:...::...|..:|.::||||:...|::.|..
Mouse   231 ATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEV 295

  Fly   318 QLLESATYNNRKVPLTL-DVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVL 381
            .:.::|..|....|.|: |...|....|...|..|.|....:......|...:...::|....|.
Mouse   296 IIRKAAKINGIVAPSTIFDPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVG 360

  Fly   382 YNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLL 446
            |..:.|...||.. .::||...:...|:....:...|:.:..|.:..||:| .:.|....|:.|:
Mouse   361 YFGLSLDTPNLNG-NIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSL-FLGGSVLLLVQLV 423

  Fly   447 PETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPFL 511
            |.   :...:...||  ::.|...:::.:::...|:|:.....|.:.:....:.||:..:..|:.
Mouse   424 PS---DLHYLSTTLV--MVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF 483

  Fly   512 SCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT 560
            ..|......:|..::.::..:..:    :..::     |:.|.|..|.|
Mouse   484 VYLGAYDRRLPYILMGSLTILTAI----ITLFF-----PESSGVSLPET 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	110/539 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	80/388 (21%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	114/560 (20%)
		MFS	123..513	CDD:119392	83/416 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850