Protein Alignment CG4459 and SLC22A15

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_060890.2
• Gene: SLC22A15 / 55356
• HGNCID: 20301
• Length: 547
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 124/609 - (20%)
• Similarity: 225/609 - (36%)
• Gaps: 118/609 - (19%)

  Fly    17 ELDVVEQVNGSFGRWQLRTILLIFLCKI-------PSAWFTAIIIYTAPYPWK-GELVCHPADWN 73
            |::...|..|..|.:|:   .|.||..:       ..|...|::..|..|.|. .||:.:.:..|
Human     2 EVEEAFQAVGEMGIYQM---YLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSHGN 63

  Fly    74 VSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLP 138
            .|..:.:                         |:.:.|    :.::|.|.:
Human    64 QSAGEDQ-------------------------AFGDWL----LTANGSEIH-------------- 85

  Fly   139 CEHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQ 203
             :||...:.:.|:.|::.||.:|...|:...||...|..:|.:.......:...:::.|.|....
Human    86 -KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149

  Fly   204 IFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELFWSMGLVLL 268
            |......|...:|:.....|.|..:....|......:||:........:..::..||:::|:...
Human   150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQY 214

  Fly   269 PAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATY----NNRK 329
            ..:..:..:|..|.:.::....|:..|..:|.::||||....|:..|     |.|.|    .|||
Human   215 ALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEA-----EEALYLIAKRNRK 274

  Fly   330 VPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMIRNLGA 394
            :..|.  .||..||   :..::..|:..::.........:.:..||....::|..:.|...:||.
Human   275 LKCTF--SLTHPAN---RSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGG 334

  Fly   395 QQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGN------LMIIAGLSTYLIWLLPETER-- 451
             .::.|.|..|..|:....:.:|||     :.:|.|.      .:.:.||:..::..|||.:.
Human   335 -SIYANLALSGLIEIPSYPLCIYLI-----NQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTG 393

  Fly   452 -----NSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPFL 511
                 ||..:.      |:.|:..||:..::...|||:.....|.|.:.:...||||..:..||:
Human   394 VFAVVNSHSLS------LLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFI 452

  Fly   512 SCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT--------YRR--QSA 566
            ..|..:...:|..:....|...||....|         |:....|...|        |||  :.|
Human   453 PSLKYVQWSLPFIVFGATGLTSGLLSLLL---------PETLNSPLLETFSDLQVYSYRRLGEEA 508

  Fly   567 IIL-----RRCSTVSSDCSAYSNE 585
            :.|     ::|....|...:.|.|
Human   509 LSLQALDPQQCVDKESSLGSESEE 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	108/534 (20%)
		MFS	164..540	CDD:119392	83/392 (21%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	80/379 (21%)
		MFS_1	111..450	CDD:284993	76/360 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..547		3/11 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940