DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and CG12783

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001262644.2	Gene:	CG12783 / 42019	FlyBaseID:	FBgn0038448	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	104/506 - (20%)
Similarity:	187/506 - (36%)	Gaps:	137/506 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 ICSRRVLVALTQSFHALGALIGGLM------AYSALKKISPRRLMLLGMIGQIFCGNLTGLVD-- 214
            :|..|:..|...|..|.|.:  |::      .|...||  .||..||   ..|...||..|..
  Fly    46 VCDLRMNEAQLASLTAAGFM--GIICSSYFWGYITDKK--GRRWTLL---RTITISNLCSLASMF 103

  Fly   215 --TYQLHIYFRCLTSIFCA----------LMYTSGQFILNDIT-----SGKARIIVVTLSELFWS 262
              |:......|.:|.||.|          ..:.|.:.::..||     :|.|.|.....:.||.|
  Fly   104 TVTFTGFFVMRFITCIFVAGPSFVAATYLSEFCSHRIMVRSITHLYMFTGFAMISCPAWATLFLS 168

  Fly   263 MGLV-----LLPAISIYFDNWS-----YLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALR 317
            .||:     |:.::::  ..|.     |:...:.:.|::|:     :.::|::||.....:..|
  Fly   169 SGLIEFEEKLVGSLTL--RPWRVLGCLYILPGVVAFLLLLL-----LPESPKFLLMIGETKRGL- 225

  Fly   318 QLLESATYNNRKVPLTLD--VQLTMYANDLDQKSKQKHS--YCQVWDGETKRSQLVYIHLIWGG- 377
            ..:|..:..|....|:.|  .:|..|...:..|.:::|.  :..:.|     ..:..:...:||
  Fly   226 DTMEWISRKNTGRTLSEDQMKRLLAYQEHVQVKRRKEHQNFFRSMLD-----DAMPLVRKPYGGY 285

  Fly   378 ----AMVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGL 438
                .||:: ::.|:...||.                     .|..:..|.:.| .||   ..|:
  Fly   286 FTCVCMVMF-VLGLLTHGLGI---------------------WYTAMRNRCNMR-QGN---TNGM 324

  Fly   439 STYLIWLLPET----ERNSRRVGLELVFWLILKIANSASI-----AVLTTCT-SEIVSKEKRVVL 493
            :...:..:|||    |..|   .|::|.....|..|.:.:     .||...: :.:....|:|:.
  Fly   325 TFCQVLFVPETGPFIETES---DLDVVCSDSFKGFNDSFVLGFVYVVLYNISWASLFCVHKKVMF 386

  Fly   494 MLSVISFSRVCLLFCPFLSCLTVIHHLVP----ITILATMGWIYGLALRRLNRYYWNTEQPQISQ 554
            :.|:::.|....|.      :...:|::.    :.::|..|.|.||....|           :..
  Fly   387 VFSLVASSTFGFLL------IFATNHMLQLFSLVFLIAFPGIIIGLLGGSL-----------LVF 434

  Fly   555 VPTPNTYRRQSAIILRRCSTVSSDCSAYSNELL--SNFERN-----MAVSI 598
            ||   ||.|..|:.:   |.:...|.|....:|  |..:.|     :|:||
  Fly   435 VP---TYLRGKALCI---SLMWCRCGAAFGAMLVGSKIQYNCELFLLAISI 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	87/435 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	86/433 (20%)
CG12783	NP_001262644.2	synapt_SV2	<2..>310	CDD:130366	61/305 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458169
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030