DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and slc22a2

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	585	Identity:	140/585 - (23%)
Similarity:	237/585 - (40%)	Gaps:	108/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYT--APYPWKGELVCHPADWNVSRSQTEH 81
            :::|:. |:|||.|:|......|..||.::....|::.  .|..|     |.  |..||..
Zfish     6 EILEEA-GTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHW-----CR--DPGVSEI---- 58

  Fly    82 VDRNHPLW--QDARSTDRLFNVDVCNAYSNSLARGFVRSHGQ------EWNAS--QSKEPGGQ-- 134
              |....|  ||||..    .|.:.|..|.:       |:.|      :|||:  ..:.|.|.
Zfish    59 --RERCGWSLQDARRA----TVPLINGSSGA-------SYSQCGRFDVDWNATGLSCENPDGDFN 110

  Fly   135 ----SSLPCEHVEHRTDY-----KSLISQFDLICSRRVLVALTQSFHALGALIG----GLMA--Y 184
                |.:|........:|     :|.:::|||:|.....|.:.|:..::|.|:|    |.:|  |
Zfish   111 QSQLSVMPMMSCVDGWEYDYVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKY 175

  Fly   185 SALKKISPRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKA 249
            ..:|..    ||....||  ..|.|......|...:.||.|........:..|..::.::.....
Zfish   176 GRMKSF----LMTNFFIG--VTGILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDH 234

  Fly   250 RIIVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEA 314
            |..|....:||:|||::|||.::.:..||.:|.|..:...|..:..:.:|.::|||||...::..
Zfish   235 RRTVGVTYQLFFSMGILLLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQNKIAE 299

  Fly   315 ALRQLLESATYNNRKVPLTLDVQL-TMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGA 378
            |: ::.:|....|||   ||..:: |:..:::|..|..  |:..::.....|:....:...|..:
Zfish   300 AV-EITKSIAKENRK---TLSKKIETLKDDNIDSGSTA--SFMDLFKTAKLRTYTFILSFNWFTS 358

  Fly   379 MVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLI 443
            .|:|..:::.:..||. .|:|:....|..|:...|:.|..|....|...:| ...|:||.:..:.
Zfish   359 AVVYQGLIMRLGILGG-NVYVDFLISGIVELPAAFLILLTIERIGRRLPFA-TANIVAGAACLIT 421

  Fly   444 WLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIV-----SKEKRVVLMLSVISFSRV 503
            ..:|::           :|||...:|....:.:  |...|:|     .....|:..|.|    .|
Zfish   422 AFIPDS-----------MFWLKSAVACVGRLGI--TMAFEMVVFVNTELYPTVIRNLGV----SV 469

  Fly   504 CLLFC-------PFLSC-LTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT 560
            |...|       |||.. |.||...:|:.|...:.::.|..:..|         |:...||.|.|
Zfish   470 CSTLCDVGGIVAPFLLYRLAVIWLELPLIIFGALAFVAGGLVLLL---------PETKGVPLPET 525

Fly 561 560
Zfish 526 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	133/552 (24%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	93/395 (24%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	138/576 (24%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	94/408 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840