DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and slc22a7b.1

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_021322800.1	Gene:	slc22a7b.1 / 393320	ZFINID:	ZDB-GENE-040426-1311	Length:	560	Species:	Danio rerio

Alignment Length:	586	Identity:	128/586 - (21%)
Similarity:	231/586 - (39%)	Gaps:	118/586 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCH--------------- 68
            :::::.:| |||:|:..::|:|:.:|           |.|        ||
Zfish    15 NILDETDG-FGRYQIALVMLLFIPRI-----------TIP--------CHFLLNNFIAAIPSHHC 59

  Fly    69 -----PADWNVSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQS 128
                 .||...:.:|.|.:..:.|..:|.....       |:.:::...:..:       |:|.|
Zfish    60 DISSLDADGLGNLTQKERLIVSVPAQEDGTPAS-------CHMFAHPQFQLLI-------NSSSS 110

  Fly   129 KEPGGQSSLP---CE---HVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSAL 187
                  |:||   |:   |.::.|...:|.:||||:|.:|.|...:.:...:|.:.|.:......
Zfish   111 ------SALPVVECQNGWHFDNSTFISTLATQFDLVCDKRGLAKASATIFFVGVMCGAVFFGVLC 169

  Fly   188 KKISPRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDI--TSGKAR 250
            .|...|.::|:..:..|.....:....:|.:...||.||.:  ||...|...::..|  ...|.|
Zfish   170 DKYGRRSMLLVSYVFSIVFSVTSAFSSSYIMFAAFRFLTGL--ALTGISNISVVLSIEWVDTKHR 232

  Fly   251 IIVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAA 315
            ..:.....:.||:|.:||...:....:|..|.|.:::.|.:......||.|:.|||:.:.:.|.|
Zfish   233 TFMGLFGSMSWSIGNMLLAGFAFMVTDWRLLIVIVTAPLFLATATWWWIPDSARWLIANGKTETA 297

  Fly   316 LRQLLESATYN------NRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQL----VY 370
            .:.|.:.||:|      :|..|.||...:|     :|.:.   |||..:  ...|..||    ::
Zfish   298 YKYLHKCATFNQRLDFTSRVKPETLSTVVT-----VDHRG---HSYTYL--DLVKTPQLRKLTLF 352

  Fly   371 IHLIWGGAMVLYNIILLMIRNLGAQQ--VHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLM 433
            ..::|.|....|..|.|.|...|...  .|...||:.....:.::..|..:  .||:.: .|.|
Zfish   353 TGIVWYGVASTYYGISLNITGFGLDPYLTHFIYAAIEVPAKILVYFSLNKV--GRRNTQ-TGTL- 413

  Fly   434 IIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVI 498
            ::.|. ..||.::..||..:.|.    |..::.|..:.||...:...|:|:..    .|:..:.:
Zfish   414 VLTGF-CILINIITPTEYWTFRT----VIAVLGKGLSEASFTTVILYTTELYP----TVMRQNGL 469

  Fly   499 SF----SRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPN 559
            .|    :|:.....|.:..|..|..|:|..|..:|....|:....|         |:.:....|.
Zfish   470 GFTNFMARMGASISPLIMLLEDIWKLLPEVIFCSMAIFCGIIALLL---------PETNNASLPE 525

  Fly   560 T 560
            |
Zfish   526 T 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	124/553 (22%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	89/393 (23%)
slc22a7b.1	XP_021322800.1	Sugar_tr	22..526	CDD:331684	127/577 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840