Protein Alignment CG4459 and SLC22A25

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_016873173.1
• Gene: SLC22A25 / 387601
• HGNCID: 32935
• Length: 577
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 120/595 - (20%)
• Similarity: 210/595 - (35%)
• Gaps: 210/595 - (35%)

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCHPADWNVSRSQTEHVD 83
            |:::|| |..||:|:  :.::||     ..|..|:.:..........:.....| |.....:.:.
Human     5 DLLDQV-GGLGRFQI--LQMVFL-----IMFNVIVYHQTQLENFAAFILDHRCW-VHILDNDTIP 60

  Fly    84 RNHPLWQDARSTDRLFNVDVCNAYSNSL----ARGFVRSHGQEW----------NASQ-SKEP-- 131
            .|.|   ...|.|.|..:.:  .:.::|    .|.||  |.| |          |.|: ..||
Human    61 DNDP---GTLSQDALLRISI--PFDSNLRPEKCRRFV--HPQ-WKLIHLNGTFPNTSEPDTEPCV 117

  Fly   132 ----GGQSSLPCEHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISP 192
                ..|||.|          .::::::||:|..:.|.::.:.....|.::||.: |..|....|
Human   118 DGWVYDQSSFP----------STIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNL-YGHLSDRKP 171

  Fly   193 RRLMLLGMIGQIFCGNLTGL---VDTYQLHIY-----------------------FRCLTSIFCA 231
                 |.....:......||   :..:|.|::                       |.....::|:
Human   172 -----LSSPNHVSTDCDEGLEVPIAIHQHHVFWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCS 231

  Fly   232 LMYTSG----QFILNDITSGKARIIVVTLSELFWSMGLVL-----------LPAISIYFDNWSYL 281
            |.:.:|    ..|:|.:.     :||..::..|.:|.|.|           |.:::....:...|
Human   232 LRFLAGAATFSIIVNTVL-----LIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCIL 291

  Fly   282 YVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYN---NRKVPLTLDVQLTMYAN 343
            .:.:|:...|.....||:|::.|||:.:.:.|..|::|.::|..|   |.:..||::|..:....
Human   292 QLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQ 356

  Fly   344 DLDQKSKQKHSYCQV------------------------WDGETKRSQ-----LVYIHLIWGGAM 379
            :|:...| |||.|::                        | |.|...|     :..:..::|...
Human   357 ELEAAQK-KHSLCELLRIPNICKRICFLSFVRFASTIPFW-GLTLHLQHLGNNVFLLQTLFGAVT 419

  Fly   380 VLYNII---------------LLM-----------------------IRNLGAQQVHVNTAAMG- 405
            :|.|.:               |||                       :..||     |..|::|
Human   420 LLANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLG-----VGAASLGI 479

  Fly   406 -------------------------FAEMVGLFVGLYLIL--YTR-RHWRWAGNLMIIAGLSTYL 442
                                     ||.:.|....|.:||  |:| ..|...|...|::||   :
Human   480 TCSTAQENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGL---V 541

  Fly   443 IWLLPETERN 452
            :.||||| ||
Human   542 VLLLPET-RN 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	117/588 (20%)
		MFS	164..540	CDD:119392	84/429 (20%)
SLC22A25	XP_016873173.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840