DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	125/602 - (20%)
Similarity:	229/602 - (38%)	Gaps:	111/602 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PELDVVEQVNGSFGRWQ-LRTILLIFLCKIPSAWFTA---IIIYTAPYPWKGELVCHPADWNVSR 76
            |||  :::|.|. ||:| |:.:.|:    .|..|.|.   :..::|..|       |...|
  Rat     4 PEL--LDRVGGR-GRFQLLQAVALV----TPILWVTTQNMLENFSAAVP-------HHRCW---- 50

  Fly    77 SQTEHVDRNHPLWQDARSTDRL---FNVDVCNAYS-----NSLARGFVRSHGQEWNASQSKEP-- 131
                     .||..::.|...:   |..||..|.|     :......:|....:|...:|...
  Rat    51 ---------VPLLDNSTSQASIPGDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTAT 106

  Fly   132 --GGQSSLPCEH---VEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKIS 191
              ....:.|||.   .:|.|...::::.:||:|..:.|..:.||....|.|:|..:...|..:..
  Rat   107 NWSDADTEPCEDGWVYDHSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFG 171

  Fly   192 PRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCL-----------TSIFCALMYTSGQ------- 238
            .||::....:.....|.:..|:.|:.|:..||.|           |:..|......|:
  Rat   172 RRRVLTWSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDP 236

  Fly   239 -------FILNDITSGKARIIVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLH 296
                   ..:.:.||.:|..:::||:.|.:|.|.||..:::....:|..|.:|:|:...:.....
  Rat   237 ELTPSLLLAVMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYS 301

  Fly   297 RWIADAPRWLLQHQRVEAALRQLLESATYNNRKVPL-TLDVQLTMYANDLDQKSKQK-------- 352
            .|:.::.|||:...|::.:||:|...|..|.||... ||.|::...|...:....|.
  Rat   302 WWLPESARWLITVGRLDQSLRELQRVAAVNRRKAEADTLTVEVLRSAMQEEPNGNQAGARLGTLL 366

  Fly   353 HSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLY 417
            |:       ...|.:.....|.|......:..:.|.::.||: .:.:..|.:|..::......|.
  Rat   367 HT-------PGLRLRTFISMLCWFAFGFTFYGLALDLQALGS-NIFLLQALIGIVDLPVKMGSLL 423

  Fly   418 LILYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTS 482
            |:....|....|.:| ::.||......|:|      |.:|   :....|.:....|:....||.:
  Rat   424 LLSRLGRRLCQASSL-VLPGLCILANILVP------REMG---ILRSSLAVLGLGSLGAAFTCVT 478

  Fly   483 EIVSKEKRVVLMLSVISFSRVC----LLFCPFLSCLTVIHHLVPITILATMGWIYGLALRRLNRY 543
            ...|:....|:.::.:...:|.    .:..|.:..|.|....:|:.:...:..:.|||...|
  Rat   479 IFSSELFPTVIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLL--- 540

  Fly   544 YWNTEQPQISQVPTPNT 560
                  |:...:|.|:|
  Rat   541 ------PETKNLPLPDT 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	114/566 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	84/413 (20%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	93/458 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346823
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930