DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	128/623 - (20%)
Similarity:	229/623 - (36%)	Gaps:	123/623 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ELDVVEQVNGSFGRWQLRTILLIFLCKI-------PSAWFTAIIIYTAPYPW-KGELVCHPADWN 73
            |::...|..|..|.:|:   .|.||..:       ..|...|:|..|..|.| ..||:.:.:..|
  Rat     2 EVEEAFQAVGEMGLYQM---YLCFLLAVLLQLYVATEAILIALIGATPAYHWDMAELLPNQSHSN 63

  Fly    74 VSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLP 138
            .|..:.:                         |:.:.|    :.::|.|.:
  Rat    64 QSSGKGQ-------------------------AFGDWL----LTANGSEIH-------------- 85

  Fly   139 CEHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQ 203
             :||.....:.|:.|::.||.:|...|:...||...|..:|.:.......:...:::.|.|....
  Rat    86 -KHVHFSNSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALD 149

  Fly   204 IFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELFWSMGLVLL 268
            |......|...:|:.....|.|..:....|......:||:........:..::..||:::|:...
  Rat   150 ILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQY 214

  Fly   269 PAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATY----NNRK 329
            ..:..:..:|..|.:.::....|:..|..:|.::||||....|:..|     |.|.|    .|||
  Rat   215 ALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEA-----EEALYLIAKRNRK 274

  Fly   330 VPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMIRNLGA 394
            :..|.  .||..||   :..::..|:..::.........:.:..||....::|..:.|...:||.
  Rat   275 LKCTF--SLTHPAN---RSYRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGG 334

  Fly   395 QQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGN------LMIIAGLSTYLIWLLPETER-- 451
             .::.|.|..|..|:....:.:|||     :.||.|.      .:.:.||:..::..|||.:.
  Rat   335 -SIYANLALSGLIEIPSYPLCIYLI-----NQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTG 393

  Fly   452 -----NSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPFL 511
                 ||..:.      |:.|:..||:..::...|||:.....|.|.:.:...||||..:..||:
  Rat   394 VFAVVNSHSLS------LLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFV 452

  Fly   512 SCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT--------YRR--QSA 566
            ..|..:...:|..:....|...||....|         |:....|...|        |||  :.|
  Rat   453 PSLKDVQWSLPFIVFGATGLTSGLLSLLL---------PETLNSPLLETFSDLQMYSYRRLGEEA 508

  Fly   567 IILR---------RCSTVSSDCSAYSNELL-SNFERNM 594
            :.|:         :.|::.|:......|.. :|.|..|
  Rat   509 LSLQTLDPPQPLGKASSLGSESEEEEEEFYDANEETQM 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	110/534 (21%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	84/392 (21%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	81/379 (21%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	77/360 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940