DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	122/572 - (21%)
Similarity:	232/572 - (40%)	Gaps:	89/572 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EQVNGSFGRWQLRTILLIFLCK---IPSAWFTAIIIYTAPYPWKGELVCHPADWNVSRSQTEHVD 83
            ::|....|.|.....|:.||..   ||:.:....|::.|..|....||.|..  |:|.:.
  Rat     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTV--NLSSAW----- 62

  Fly    84 RNH--PL-WQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEHVEHR 145
            |||  || .:|.|...:     .|..|..:....|         ::...|||....|  |.:|..
  Rat    63 RNHSIPLETKDGRQVPQ-----SCRRYRLATIANF---------SALGLEPGRDVDL--EQLEQE 111

  Fly   146 T-----DY------KSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLG 199
            .     :|      .::::::||:|.......||.|...:|.|:|..::.....:...:.::.|.
  Rat   112 NCLDGWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLT 176

  Fly   200 MIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQ-------FIL-NDITSGKARIIVVTL 256
            |      |..||........:.|...|.:|  ::...||       |:| .:|.|...|||..||
  Rat   177 M------GMQTGFSFLQLFSVNFEMFTVLF--VLVGMGQISNYVAAFVLGTEILSKSIRIIFATL 233

  Fly   257 SE-LFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLL 320
            .. :|::.|.::||..:.:..:|..|.:|::...::...|..:|.::||||:...||:.|...:.
  Rat   234 GVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIR 298

  Fly   321 ESATYNNRKVPLTL----DVQLTMYANDLDQKSKQKHSYCQVWD-GETKRSQLVYIH--LIWGGA 378
            ::|.:|....|.|:    ::|      ||:.|..|.|   .::| ..|:..:::.|.  ::|...
  Rat   299 KAAKFNGIVAPSTIFDPSELQ------DLNSKKPQSH---HIYDLVRTRNIRIITIMSIILWLTI 354

  Fly   379 MVLYNIILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLI 443
            .|.|..:.|...||.. .::||...:...|:....:...|:.:..|.:..:..| .:.|.....|
  Rat   355 SVGYFGLSLDTPNLHG-DIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAAL-FLGGSVLLFI 417

  Fly   444 WLLPETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFC 508
            .|:|     |....|.....::.|...:::.:::...|:|:.....|.:.:....:.||:..:..
  Rat   418 QLVP-----SELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS 477

  Fly   509 PFLSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT 560
            |:...|......:|..::.::..:..:    |..::     |:....|.|:|
  Rat   478 PYFVYLGAYDRFLPYILMGSLTILTAI----LTLFF-----PESFGAPLPDT 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	116/542 (21%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	81/391 (21%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	120/563 (21%)
		MFS	123..510	CDD:119392	85/419 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840