Protein Alignment CG4459 and SLC22A24

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_001129978.2
• Gene: SLC22A24 / 283238
• HGNCID: 28542
• Length: 552
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 122/609 - (20%)
• Similarity: 237/609 - (38%)
• Gaps: 153/609 - (25%)

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIII--YTAPYP----W---------------- 61
            ||:....|..||:|:  .|:.|.|......|..|::  :||..|    |
Human     4 DVLLDQVGGMGRFQI--CLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDTGT 66

  Fly    62 --KGEL--VCHPADWNVSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQE 122
              |.:|  :..|.|.|:...:.:..  .||.||       |.:::  ..:.|
Human    67 LSKDDLLRISIPLDSNLRPQKCQRF--IHPQWQ-------LLHLN--GTFPN------------- 107

  Fly   123 WNASQSKEPGGQSSLPCEH--VEHRTDYKS-LISQFDLICSRRVLVALTQSFHALGALIGGLMAY 184
                 :.||..:   ||..  |..|:.:.| :::::||:|..:.|.::.||....|:|:|||: |
Human   108 -----TNEPDTE---PCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLI-Y 163

  Fly   185 SALKKISPRRLMLLGMIGQIFCGN-LTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILN-DITSG 247
            ..|.....|:::......|:...| ......|:.::...|.|.. |..:......|||: :.|..
Human   164 GHLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAG-FSTMTILGNTFILSLEWTLP 227

  Fly   248 KARIIVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRW-IADAPRWLLQHQR 311
            ::|.:.:.:....:|:|.:||..::....:|..|.:.:|:.:||| :|..| :.::.|||:.:.:
Human   228 RSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVL-FLSSWKMVESARWLIINNQ 291

  Fly   312 VEAALRQLLESATYNNRK---VPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHL 373
            ::..|::|...|..|.:|   ..||.::..:....:|| ..:.|.|...::.....|.::..:..
Human   292 LDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELD-AVRIKTSIFSLFRAPKLRMRVFGLCF 355

  Fly   374 IWGGAMVLYNIILLMIRNLGA--QQVHVNTAAMGF-AEMVGLF-----------------VGLYL 418
            :.....|.:..::|.:::||:  ....:...|:.| |..|.|.                 |||::
Human   356 VRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFI 420

  Fly   419 ILYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSRRVGLELVFWLILKIANSASI-------AV 476
            ::.|                      .||:..:..|.|...|....:...:||||:       .:
Human   421 LVNT----------------------FLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTI 463

  Fly   477 LTTCTSEIVSKEKR-----VVLMLSVISFSRVCLLFCPFLSCLTVIHHLVPITILATMGWIYGLA 536
            |.:..:.|.:...|     ..|:::::::|.    ..|::|........||:.:|.
Human   464 LRSTVAGINAVSGRTGAALAPLLMTLMAYSP----HLPWISYGVFPILAVPVILLL--------- 515

  Fly   537 LRRLNRYYWNTEQPQISQVPTPNT 560
                         |:...:|.|||
Human   516 -------------PETRDLPLPNT 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	115/576 (20%)
		MFS	164..540	CDD:119392	81/413 (20%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	91/461 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153520
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840