DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4459 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	558	Identity:	117/558 - (20%)
Similarity:	219/558 - (39%)	Gaps:	127/558 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYP----WKGELVCHPADWNVSR--S 77
            |::.|: ||.||:|:..::.:.:|...||..|.:..:||..|    |...|....|..|.||  |
Mouse     5 DLIIQI-GSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNGSRILS 68

  Fly    78 QTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSK-------EPGGQS 135
            |.:.:..:.||       |.....|.|..|..           .:|:.....       ||..:
Mouse    69 QDDLLRISIPL-------DSNLRPDKCRRYIQ-----------PQWHLLHLNGTFPTVTEPDTE- 114

  Fly   136 SLPCEH---VEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLML 197
              ||..   .:..|...:.::|:||:|..:.|.::.:..:..|..||.:|......|...:.:..
Mouse   115 --PCVDGWVYDQSTFLSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFT 177

  Fly   198 LGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSGKARIIVVTLSELFWS 262
            ..::.............::.::...|.|:.||.:.:.|:...::.:.||.|.:.:|:.|..:...
Mouse   178 CSLLKMAITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASG 242

  Fly   263 MGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYN- 326
            :|..||..::..|.||.:|.:|:|..:.:|:...||::::.|||:...:.:.:|::|.::|..|
Mouse   243 VGQTLLGGLAFAFRNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVNR 307

  Fly   327 --NRKVPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMI 389
              |....|||:|..|:...:|:.             .:||.|.|                .|...
Mouse   308 IKNSGDALTLEVVKTIMKEELEA-------------AQTKPSPL----------------DLFRT 343

  Fly   390 RNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSR 454
            .||     ......:.|...|.:...|.|::          |:..::. :.:|
Mouse   344 PNL-----RKRICLLSFVRFVSVMSLLGLLI----------NIQYLSN-NVFL------------ 380

  Fly   455 RVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCP--------FL 511
               |:.::.::...||     ||...:...:.:....::.:||:..|.:.::|.|        ||
Mouse   381 ---LQCLYGVVCIPAN-----VLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQILRVFL 437

  Fly   512 SCL-----------TVIH--HLVPITILATMGWIYGLA 536
            |.|           |::|  .|||..|.||...:.|:|
Mouse   438 STLGGAISSASITSTLVHANELVPTIIRATALGVVGIA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	114/549 (21%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	79/397 (20%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	115/551 (21%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843626
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840