DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4459 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	534	Identity:	108/534 - (20%)
Similarity:	211/534 - (39%)	Gaps:	74/534 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVCH----PADWNVSRSQT 79
            |:::|| |..||:||..:.::....:..|....:..:||..|      .|    ||:.|:|:
Mouse     5 DLLKQV-GGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIP------AHHCRPPANANLSK--- 59

  Fly    80 EHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPGGQSSLPCEHVEH 144
               |.....|.......|          ..|..|.....:|.|.|.:...||    .|.....::
Mouse    60 ---DGGLEAWLPLDKQGR----------PESCLRFPFPHNGTEANGTGVTEP----CLDGWVYDN 107

  Fly   145 RTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLMLLGMIGQIFCGNL 209
            .|...:::::::|:||.|....|.||...:|.|:|.:|......::..|::::|..:.....|..
Mouse   108 STFPSTIVTEWNLVCSHRAFRQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTC 172

  Fly   210 TGLVDTYQLHIYFRCLTSIFCALMYTSGQFILNDITSG------KARIIVVTLSELFWSMGLVLL 268
            ......|.::..||.|:.:..|      ...:|.:|..      ..|..|.||....:|:|..||
Mouse   173 AAYAPNYTVYCIFRLLSGMSLA------SIAINCMTLNMEWMPIHTRAYVGTLIGYVYSLGQFLL 231

  Fly   269 PAISIYFDNWSYLYVAISSSLIVLVWLHRW-IADAPRWLLQHQRVEAALRQLLESATYNNRK--- 329
            ..|:....:|.:|.:|:|....| .:::.| ..::.||.....|::..||.|...|..|.::
Mouse   232 AGIAYAVPHWRHLQLAVSVPFFV-AFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEG 295

  Fly   330 VPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHLIWGGAMVLYNIILLMIRNLGA 394
            ..|:::|..|....:| ..:|.:.|..::....|.|...:.:.::|......|..:::.::..|.
Mouse   296 AKLSIEVLQTSLQKEL-TLNKGQASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGV 359

  Fly   395 QQVHVNTAAMGFAEMVGLFVGLYLILYT--RRHWRWAGNLMIIAGLSTYLIWLLPETE---RNSR 454
             .:::.....|..::...|| .:|::.:  ||..:.|.  :::||:...:..::|...   |.|
Mouse   360 -SMYLIQVIFGAVDLPAKFV-CFLVINSMGRRPAQLAS--LLLAGICILVNGIIPRGHTIIRTS- 419

  Fly   455 RVGLELVFWLILKIANSASIAVLTTC----TSEIVSKEKRVVLMLSVISFSRVCLLFCPFLSCLT 515
                       |.:.....:|....|    |.|:.....|...:....:.:||..:..|.:|...
Mouse   420 -----------LAVLGKGCLASSFNCIFLYTGELYPTMIRQTGLGMGSTMARVGSIVSPLISMTA 473

  Fly   516 VIHHLVPITILATM 529
            ..:..:|:.|...:
Mouse   474 EFYPSIPLFIFGAV 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	105/527 (20%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	75/385 (19%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	105/527 (20%)
		MFS	129..499	CDD:119392	75/383 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840