Protein Alignment CG4459 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 122/618 - (19%)
• Similarity: 222/618 - (35%)
• Gaps: 148/618 - (23%)

  Fly    18 LDVVEQVNGSFGRWQ-LRTILL----IFLC----------KIPS--AWFTAIIIYTAPYPWKGEL 65
            ||:|    |..||:| |:|:.|    ::||          .:||  .|...:...||.....|.|
Human     7 LDLV----GGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSL 67

  Fly    66 -------VCHPADWNVSRSQTEHVDR--NHPLWQ--DARSTDRLFNVDVCNAYSNSLARGFVRSH 119
                   :..|...|    |..|..|  ..|.||  |..:|
Human    68 SPEALLAISIPPGPN----QRPHQCRRFRQPQWQLLDPNAT------------------------ 104

  Fly   120 GQEWNASQSKEPGGQSSLPCEH--VEHRTDYKS-LISQFDLICSRRVLVALTQSFHALGALIGGL 181
            ...|:.:.::        ||..  |..|:.:.| ::::::|:|....|..:.||.:..|.|:|..
Human   105 ATSWSEADTE--------PCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAA 161

  Fly   182 MAYSALKKISPRRLMLLGMIGQIFCGNLTGLVDTYQLHIYFRCLTSIFCA--LMYTS-------- 236
            ....|..:...|.::....:.....|........:.::..||.|.:...|  :|.|.
Human   162 ACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTW 226

  Fly   237 ---------------GQFILNDITSGKARIIVVTLSELFWSMGLVLLPAISIYFDNWSYLYVAIS 286
                           |...:.:.|:.:||.:|:||:.|.:|.|..|..|::....:|:.|.:.:|
Human   227 RHAGGLHAGSRAEPLGLLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVS 291

  Fly   287 SSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYNNR---KVPLTLDVQLTMYANDLDQK 348
            ....:......|:|::.||||...|::..|::|...|..|.:   :..||.:|.|:....:|..
Human   292 VPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSM- 355

  Fly   349 SKQKHSYCQVWDGETKRSQLVYIH------------LIWGGAMVLYNIILLMIRNLGAQQVHVNT 401
                        |:...|....:.            |.|......:..:.|.::.||: .:.:..
Human   356 ------------GQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGS-NIFLLQ 407

  Fly   402 AAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLPETERNSRRVGLELVFWLIL 466
            ..:|..::......|.|:.:..|....|.:| ::|||......|:|. |..:.|..        |
Human   408 MFIGVVDIPAKMGALLLLSHLGRRPTLAASL-LLAGLCILANTLVPH-EMGALRSA--------L 462

  Fly   467 KIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVC----LLFCPFLSCLTVIHHLVPITILA 527
            .:.....:....||.:...|:....||.::.:...::.    .:..|.:..|.|....:|:.:..
Human   463 AVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYG 527

  Fly   528 TMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT 560
            |:..:.|||...|         |:...:|.|:|
Human   528 TVPVLSGLAALLL---------PETQSLPLPDT 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	112/584 (19%)
		MFS	164..540	CDD:119392	80/419 (19%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	118/608 (19%)
		MFS	122..541	CDD:119392	85/451 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153238
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840