Protein Alignment CG4459 and SLC22A7

DIOPT Version :9

• Sequence 1: NP_650850.1
• Gene: CG4459 / 42377
• FlyBaseID: FBgn0038753
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 144/641 - (22%)
• Similarity: 239/641 - (37%)
• Gaps: 144/641 - (22%)

  Fly    19 DVVEQVNGSFGRWQLRTILLIFLCKIPSAWFTAIIIYTAPYP-WKGELVCHPADWNVSRSQTEHV 82
            :::||| |.||.:|||.:.|:.|.::.......:.|:.|..| .:..|...||:::       |.
Human     5 ELLEQV-GGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFS-------HQ 61

  Fly    83 DRNHPLWQDA---RSTDRLFNVDVCNAYSNSL----------ARGFVR--------SHGQEWNAS 126
            |    :|.:|   |..|...:..:..||..:|          :||.:.        |.|.|::.|
Human    62 D----VWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHS 122

  Fly   127 --------------------------QSKEPGGQSSLPCEHVE--------------HRTDYKSL 151
                                      ||........||.|..|              .|.....|
Human   123 EFSSTIATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSWRESLGGL 187

  Fly   152 IS--QFDLICSRRVLVALTQSFHALGALIGGLMAYSALK-KISPRRLMLLGMIGQIFCGNLTGLV 213
            :|  ::||:|.::.|.....:|...|.|:|. :|:..|. :...|||:|:..:..:..|..:...
Human   188 LSGMEWDLVCEQKGLNRAASTFFFAGVLVGA-VAFGYLSDRFGRRRLLLVAYVSTLVLGLASAAS 251

  Fly   214 DTYQLHIYFRCLTSI----FCALMYTSGQFILN--DITSGKARIIVVTLSELFWSMGLVLLPAIS 272
            .:|.:....|.||..    |..::...|:..|.  |:   :.|.:...||..||:.|::||..:.
Human   252 VSYVMFAITRTLTGSALAGFTIIVMPLGEAELEWLDV---EHRTVAGVLSSTFWTGGVMLLALVG 313

  Fly   273 IYFDNWSYLYVAIS---SSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYNNRKVPLTL 334
            ....:|.:|.:|::   :..|:.:|   |:.::.||||....|:.|.|.||..|..|.|.|....
Human   314 YLIRDWRWLLLAVTLPCAPGILSLW---WVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDS 375

  Fly   335 DVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLVYIHL----IWGGAMVLYNIILLMIRNLGAQ 395
            ..|..:......::..::.||..::    :..:|.:|.|    :|.|....|..:.|.:..||.
Human   376 FSQEAVSKVAAGERVVRRPSYLDLF----RTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGL- 435

  Fly   396 QVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIA-GLSTYLIWLLPETERNSRRVGLE 459
            .|:......|..|:....:....:.|..|....||.|:..| ...|.|:            |..:
Human   436 NVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLL------------VSSD 488

  Fly   460 LVFW-LILKIANSA-SIAVLTTC---TSEIVSKEKRVVLMLSVISFSRVCLLFCPFLSCLTVIHH 519
            :..| .:|.:...| |.|..||.   |||:.....|...|.......|:.....|..:.|..:..
Human   489 MKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWL 553

  Fly   520 LVP------ITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNTYR---RQSA 566
            .:|      |.:||.     |.||.          .|:..|...|.|.:   |:||
Human   554 SLPKLTYGGIALLAA-----GTALL----------LPETRQAQLPETIQDVERKSA 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	132/599 (22%)
		MFS	164..540	CDD:119392	93/401 (23%)
SLC22A7	XP_011512558.1	2A0119	11..585	CDD:273328	137/623 (22%)
		MFS	206..563	CDD:119392	86/380 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840