DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4459 and slc22a6

DIOPT Version :9

Sequence 1:	NP_650850.1	Gene:	CG4459 / 42377	FlyBaseID:	FBgn0038753	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	122/570 - (21%)
Similarity:	210/570 - (36%)	Gaps:	112/570 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SIPRKSSPELDVVEQVNGSF------GRWQLRTILLIFLCKIPSAWFTAIIIYTAPYPWKGELVC 67
            :|||...       |:||||      |.| ||.::.:    .|:..|:..:.||.|   :..|:.
Frog    43 AIPRHRC-------QINGSFEETNFTGPW-LRALVPM----KPTGEFSKCLRYTTP---QYHLLM 92

  Fly    68 HPADWNVSRSQTEHVDRNHPLWQDARSTDRLFNVDVCNAYSNSLARGFVRSHGQEWNASQSKEPG 132
            .....||...:||                             :...|:|..|.:  .||
Frog    93 DNFTQNVDELETE-----------------------------TCVDGWVYDHSE--FAS------ 120

  Fly   133 GQSSLPCEHVEHRTDYKSLISQFDLICSRRVLVALTQSFHALGALIGGLMAYSALKKISPRRLML 197
                             ::|:|:||:|:.|.:..:.||.:..|.|:|.::......|...|.|.:
Frog   121 -----------------TIITQWDLVCNHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNI 168

  Fly   198 LGMIGQIFCGNLTGLVDTYQLHIYFRCLT-SIFCALMYTSGQFILNDITSGKARIIVVTLSELFW 261
            ...:.....|........|..:..||.|| :....::..|...|:..|.:|. |....|.:...:
Frog   169 WSNLQMSVTGICAAFSPNYIWYCIFRFLTGTALSGIVLNSYSLIVEWIPTGN-RAFTSTATGYCY 232

  Fly   262 SMGLVLLPAISIYFDNWSYLYVAISSSLIVLVWLHRWIADAPRWLLQHQRVEAALRQLLESATYN 326
            :||.::|..::....:|.:|.:|.|...........||.::.|||:...:.|.|.:.|.:.|..|
Frog   233 TMGQLVLVGLAFMIRDWHWLQLAASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKIN 297

  Fly   327 NRK---VPLTLDVQLTMYANDLDQKSKQKHSYCQVWDGETKRSQLV-----YIHLIWGGAMVLYN 383
            .:|   ..||::|..:....::   |..|||...|.|  ..|:.:|     .|...|......|.
Frog   298 GKKEAGEKLTVEVLKSSMQREI---SASKHSTYSVLD--LVRTPVVRRISFCISCTWFSTSFAYY 357

  Fly   384 IILLMIRNLGAQQVHVNTAAMGFAEMVGLFVGLYLILYTRRHWRWAGNLMIIAGLSTYLIWLLP- 447
            .:.|.:::.|. .:::.....|..::...|...:::.|..|....|..| |:||::..:...:|
Frog   358 GLALDLQSFGV-SIYIIQIIFGTVDIPAKFFSYFVMTYIGRRVLQALTL-ILAGIAILVNICVPQ 420

  Fly   448 --ETERNSRRVGLELVFWLILKIANSASIAVLTTCTSEIVSKEKRVVLMLSVISFSRVCLLFCPF 510
              :|.|.|..|        ..|...:||...|...|.|:.....|...|......:|:..:..|.
Frog   421 DYQTVRTSMAV--------FGKGCLAASFNCLFLYTGELYPTVIRQSGMGLGTMMARLGGIIAPL 477

  Fly   511 LSCLTVIHHLVPITILATMGWIYGLALRRLNRYYWNTEQPQISQVPTPNT 560
            ......|:|.:|:.|...:..:.|:|         ....|:...||.|.|
Frog   478 AQMTGDIYHSLPLIIFGCLPILSGIA---------GCFLPETLGVPLPET 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4459	NP_650850.1	2A0119	26..536	CDD:273328	111/527 (21%)
CG4459	NP_650850.1	MFS	164..540	CDD:119392	84/387 (22%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	97/484 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010