Protein Alignment CG4770 and FAR1

DIOPT Version :10

• Sequence 1: NP_650848.1
• Gene: CG4770 / 42375
• FlyBaseID: FBgn0038751
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_001428171.1
• Gene: FAR1 / 84188
• HGNCID: 26222
• Length: 518
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 158/511 - (30%)
• Similarity: 262/511 - (51%)
• Gaps: 44/511 - (8%)

  Fly    14 DIYQDAVVFITGATGFVGKSLLEKLLWSFPQIKRIYMLIRPKGGVTVEERFRGFLQNPIFERIKS 78
            :.|:...|.:||||||:||.||||||.|.|::..:|:|:|.|.|.|.:||....|...:|:|::.
Human     6 EYYEGKNVLLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEVLSGKLFDRLRD 70

  Fly    79 EHPTQLKKIFHFSGNIEDDNLGLNESDRSVLCAEVNIIFHSAATVRFNECLKVSARVNSQATYNL 143
            |:|...:||...:..:....|.|:|.|:.|:....|||||.||||||||.|:.:.::|..||..|
Human    71 ENPDFREKIIAINSELTQPKLALSEEDKEVIIDSTNIIFHCAATVRFNENLRDAVQLNVIATRQL 135

  Fly   144 LELCRQMPYLRSFLYVSTAYCNPGRKYVDEQVYPTMPPVDWRQFLSATQKIPDDYLNRLADYIKG 208
            :.|.:||..|..|::|||||....||::||.|||  ||||.::.:.:.:.:.|..:|.:...:.|
Human   136 ILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYP--PPVDPKKLIDSLEWMDDGLVNDITPKLIG 198

  Fly   209 PHVNTYTFTKSIAEQIVNAYKDVIPIVIVRPSIVTAAYREPYPGWIDNIQAISGIMMEIGKGGIS 273
            ...|||.:||::||.:|......:.:.|||||||.|:::||:||||||....||:.:..|||.:.
Human   199 DRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILR 263

  Fly   274 SILGNKDLICDIIPVDFVVNAMIMMVGKAKLG------SLSICNATSGVTNPITWQHLGELTMKW 332
            :|..:.:.:.|::|||.|||..:.....:.:.      ::.:.|.|:|.|||..|..:....:..
Human   264 TIRASNNALADLVPVDVVVNMSLAAAWYSGVNRYMRPRNIMVYNCTTGSTNPFHWGEVEYHVIST 328

  Fly   333 SRIYPTRRMIMFPNFKYRCSAFNHELAVWVLHFVPALLMDLQTLLLAQKKRLVTPIAKKFRQACL 397
            .:..|..:....||.....:...:...:.|.|..||.|.|:...:..:..|::..|. :..:|.:
Human   329 FKRNPLEQAFRRPNVNLTSNHLLYHYWIAVSHKAPAFLYDIYLRMTGRSPRMMKTIT-RLHKAMV 392

  Fly   398 AGSFFSLNEWIFKNKSRFYFKEMIENGTYP----TLYWNLEEMDYDEYVRRHMIGINKYLHREKF 458
            ...:|:.|.|::..::    ..|:.|...|    |...::.::.:.||:..:.:|..||:..|:.
Human   393 FLEYFTSNSWVWNTEN----VNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCLGTKKYVLNEEM 453

  Fly   459 T------VDSNK-------------FMVTRIYW--------FWIFLHLMFYMMLVY 487
            :      ...||             .::.||:.        .|.|:..:.|..|.|
Human   454 SGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFLSY 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4770	NP_650848.1	FAR-N_SDR_e	21..337	CDD:187547	123/321 (38%)
		Sterile	363..455	CDD:460779	20/95 (21%)
FAR1	NP_001428171.1	Necessary and sufficient for PEX19-mediated localization into peroxisome membrane. /evidence=ECO:0000269|PubMed:24108123	454..510		9/56 (16%)