DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4770 and CG1441

DIOPT Version :9

Sequence 1:	NP_650848.1	Gene:	CG4770 / 42375	FlyBaseID:	FBgn0038751	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_610535.1	Gene:	CG1441 / 36029	FlyBaseID:	FBgn0033464	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	159/529 - (30%)
Similarity:	264/529 - (49%)	Gaps:	85/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDNAEVSTVEHQTDIYQDAVVFITGATGFVGKSLLEKLLWSFPQIKRIYMLIRPKGGVTVEERFR 65
            :|:.||..:   .:.::...:||||.|||:||.|:||||.|...:||||:|||||.|...:||.:
  Fly    20 IDDNEVDRI---AECFKGRSLFITGGTGFLGKVLVEKLLRSCGGLKRIYLLIRPKKGKDPQERIK 81

  Fly    66 GFLQNPIFERIK----SEHPTQLKKIFHFSGNIEDDNLGLNESDRSVLCAEVNIIFHSAATVRFN 126
            ...||.:|:::|    .||  .|:::...:|::....||::|.|...|..||:|::|.||||||:
  Fly    82 DIFQNVLFDQVKQMRGEEH--ILQQVVAIAGDVLSPGLGISEKDLETLRQEVSIVYHCAATVRFD 144

  Fly   127 ECLKVSARVNSQATYNLLELCRQMPYLRSFLYVSTAYCNPGRKYVDEQVYPTMPPVDWRQFLSAT 191
            |.|:.:..:|::.|..:|||...:.:|..|.|.|||||:...|.:.|:.|.  ||.|..:.:.|.
  Fly   145 EPLRNAVFMNTRGTKYMLELALTLKHLDFFAYCSTAYCHLHVKTLYEKPYD--PPADPHKVMQAC 207

  Fly   192 QKIPDDYLNRLADYIKGPHVNTYTFTKSIAEQIVNAYKDVIPIVIVRPSIVTAAYREPYPGWIDN 256
            :.:.||.:..:...:.|...|||.:|||:||.:|....:.:|.||:|||||...::||.|||.||
  Fly   208 EWLTDDEVATIERKVLGAIPNTYAYTKSLAEALVVEKFEELPAVILRPSIVIPIWKEPIPGWTDN 272

  Fly   257 IQAISGIMMEIGKGGISSILGNKDLICDIIPVDFVVNAMIMMVGKAKLGSLSICNATSGV--TNP 319
            |...:|:::..|||.|.::..|.....|.:|||..||.:::         .|..|.|:|.  ||.
  Fly   273 INGPTGLLIGAGKGVIRTMYCNSSGYGDFLPVDVAVNGILV---------ASWRNITAGTDKTNR 328

  Fly   320 ITWQHL---GELTMKWSRIYPTRRMIM-----------FPNFKYRCSAFNHELAVWVLHFVPALL 370
            :.  |:   .::.:.|:.|....|.::           :|....:.:.:.|.:.:.:..::|||.
  Fly   329 VA--HMTSSNDIKVSWAEIIELGRWVIENKVPLNGVAWYPGGSMKSNYWVHFICMVLFQWMPALF 391

  Fly   371 MDLQTLLLAQKK---RLVTPIAKKFRQACLAGSFFSLNEWIFKNKSRFYFKEMIEN---GTYPTL 429
            :|....:|....   |:...|.|.|.    ...:::.|.|.|.|......::::.|   .||...
  Fly   392 VDALLWILRYPPVLCRVQNRIYKGFE----VFEYYANNVWNFDNSEAVKLRKLMNNKERRTYVIE 452

  Fly   430 YWNLEEMDY----------------DEYV---RRHMIGINKYLHREKFTVDSNKFMVTRIY-WFW 474
            ...|:.:||                ||.:   ||||    |.:           ::|.::| ..|
  Fly   453 KIELDLIDYFTNCVLCARRLILKESDESIPAARRHM----KVM-----------WVVDKVYKGIW 502

  Fly   475 IF--LHLMF 481
            ||  |::::
  Fly   503 IFGILYMLY 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4770	NP_650848.1	WcaG	21..358	CDD:223528	124/356 (35%)
		FAR-N_SDR_e	21..337	CDD:187547	121/324 (37%)
		Sterile	364..455	CDD:281068	26/115 (23%)
CG1441	NP_610535.1	PLN02996	24..464	CDD:215538	145/461 (31%)
		FAR-N_SDR_e	35..348	CDD:187547	121/327 (37%)
		Sterile	385..475	CDD:281068	19/93 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466780
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.900