DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	540	Identity:	119/540 - (22%)
Similarity:	207/540 - (38%)	Gaps:	102/540 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 MGNFGPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKC--------------------- 109
            :|:||.:|::.|::|.:....:.::....:|...|    |.:.|
Human    11 IGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLD----EPHHCAVAWVKNHTFNLSAAEQLVLS 71

  Fly   110 ---DTTAF--------GPDVNSTVS--LDH-------CYVMVNYGESAYAMRQCRKFLYTTGFHS 154
               ||...        .|..|:::.  |.|       |.:...|.|:.              ..|
Human    72 VPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENR--------------LPS 122

  Fly   155 LTMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGL--- 216
            |..||:|||........:|...:.|||:|    |.:...|..|...:..|...|:...|:||
Human   123 LKNEFNLVCDRKHLKDTTQSVFMAGLLVG----TLMFGPLCDRIGRKATILAQLLLFTLIGLATA 183

  Fly   217 -VKDFSLHCGLRCLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNAP 280
             |..|.|:..||...|.:...:..|...:..:.....:|...::|..|.::||.::|.|||....
Human   184 FVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFR 248

  Fly   281 SWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSKEL 345
            :|:.:.:..|...|::.|.....|:|.||.|...:     ::..:.::.:||..|.|  |:|.||
Human   249 NWRLLQITGTAPGLLLFFYFWALPESARWLLTRGR-----MDEAIQLIQKAASVNRR--KLSPEL 306

  Fly   346 PQQLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMV--VNT----GLLLHVRSFG 404
            ..||...:..     |:.:.:.|:.       |.....:.|..|.|  |::    ||.|.|..||
Human   307 MNQLVPEKTG-----PSGNALDLFR-------HPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFG 359

  Fly   405 REHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQWAGGFAIVVGCIGSICWFLAEEDMPEVYGL 469
            .:..::. |..|..|:.....::.:..... |||...|  .:|:|.:..|.......|:|.|.
Human   360 LDVYLTQ-LIFGAVEVPARCSSIFMMQRFG-RKWSQLG--TLVLGGLMCIIIIFIPADLPVVV-- 418

  Fly   470 TLGLLMASLPQAAVACAQSMILACLGELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVSPAL 534
               .::|.:.:.|.|.|.::......||.|...|.........::|:..:....:.||.:...||
Human   419 ---TMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAAL 480

  Fly   535 SLSAFCLLVILGGLGTCCLV 554
            .:..:..|.|:.|| .|.|:
Human   481 PMLIYGSLPIVAGL-LCTLL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	118/536 (22%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	33/137 (24%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	119/539 (22%)
		MFS	139..500	CDD:119392	93/394 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850