Protein Alignment CG4465 and SLC22A6

DIOPT Version :9

• Sequence 1: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_004781.2
• Gene: SLC22A6 / 9356
• HGNCID: 10970
• Length: 563
• Species: Homo sapiens
• Alignment Length: 518
• Identity: 115/518 - (22%)
• Similarity: 201/518 - (38%)
• Gaps: 92/518 - (17%)

  Fly    92 ACILFTAPDLYPEEEYKCDTTAF--GPDVNSTVSLDHCYVMVNYGESAYAMRQCRKFLYTTGFHS 154
            :|:.||:|..         ...|  |.:.|.|.:.:.|.....|..|.:.             .:
Human    77 SCLRFTSPQW---------GLPFLNGTEANGTGATEPCTDGWIYDNSTFP-------------ST 119

  Fly   155 LTMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGLVKD 219
            :..|:||||........:|..::.|:|:|.:....|...|..|::.........:.........:
Human   120 IVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPN 184

  Fly   220 FSLHCGLR-----CLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNA 279
            |.::|..|     .||.:|...|..:.:::.....|   .|||||.|  .::||..||.|:|...
Human   185 FPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRA---CVGTLIGY--VYSLGQFLLAGVAYAV 244

  Fly   280 PSWQHIYLGVTLSLLVIVFLLPW-TPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSK 343
            |.|:|:.|.|:...... |:..| ..:|.||   |:...:|  :.|:..|...||.||:..:.:|
Human   245 PHWRHLQLLVSAPFFAF-FIYSWFFIESARW---HSSSGRL--DLTLRALQRVARINGKREEGAK 303

  Fly   344 ELPQQLEELRERMLEPMPAVHWMHLWMGQ-RRSTFHLVAV----HMALATFMV------VNTGLL 397
               ..:|.||..:.:        .|.||: :.|...|:..    |:.|...|:      ...||:
Human   304 ---LSMEVLRASLQK--------ELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLV 357

  Fly   398 LHVRSFGREHLVSNTL--AMGLAEMLGCFLALHLTFNLSERKWQWAGGFAIVVGCIGSICWFLAE 460
            :.::.||....:...:  |:.|...|..||.::   :|..|..|.|   |::   :..|| .|..
Human   358 MDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVIN---SLGRRPAQMA---ALL---LAGIC-ILLN 412

  Fly   461 EDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSCLSFSAVTWARVWQLSASFLT 525
            ..:|:...: :...:|.|.:..:|.:.:.|....|||.|...|........|.|||..:.:..::
Human   413 GVIPQDQSI-VRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVS 476

  Fly   526 LLRQVSPALSLSAFCLLVILGGLGTCCL----------VTRDKE------QPPVGAVVNKGQQ 572
            :..::.|::.|..:..:.:.....|..|          ..:|.|      |...|....||:|
Human   477 MTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQ 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	107/481 (22%)
		MFS	169..>303	CDD:119392	34/139 (24%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	108/492 (22%)
		MFS	135..505	CDD:119392	91/402 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..563		5/15 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153516
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840