DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	111/539 - (20%)
Similarity:	199/539 - (36%)	Gaps:	119/539 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 MGNFGPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKCDTTAFGPDVNSTVSLDHCYVM 130
            :|:.||:|...:.:|.|..:..|......:|||                      |..:.||...
  Rat    10 VGSMGPFQYLHVTLLALPVLGIANHNLLQIFTA----------------------TTPVHHCRPP 52

  Fly   131 VNYGESAYAM--------RQCRKF-----------------------LYTTGFHSLTMEFDLVCL 164
            .|.....:.:        .:|.:|                       :|.:...::.:|:||||.
  Rat    53 PNASIGPWVLPLDPNGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCS 117

  Fly   165 CDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMC-----------SLLMGLVK 218
            .:.....:|...:.|:|:||....:|......:.|.   .|..||.           ||.:.::
  Rat   118 SNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPIL---TWSYLMLAASGSGAAFSPSLPVYMI- 178

  Fly   219 DFSLHCGLRC-LAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNAPSW 282
             |...||  | ::.:|...:|.:.:::   .|:.:....|.|.| |: .:|..:|.|||...|.|
  Rat   179 -FRFLCG--CSISGISLSTVILNVEWV---PTSMRAISSTSIGY-CY-TIGQFILSGLAYAIPQW 235

  Fly   283 QHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSKELPQ 347
            :.:.|..:....:...|..|.|:|.||.:...|     ..:.:..|...|..||:..: .|:|
  Rat   236 RWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGK-----YSKALKTLQRVATFNGKKEE-GKKL-- 292

  Fly   348 QLEELRERMLEPMPAVHWMH----LWMGQRRSTFHLVAVHMALATFMVVNTGLLLHVRSFGREHL 408
            .:|||:..:.:.:.:....:    |:   |.|....|...::||.|   :||...:..:.|.|..
  Rat   293 TIEELKFNLQKDITSAKVKYGLSDLF---RVSILRRVTFCLSLAWF---STGFAYYSLAMGVEEF 351

  Fly   409 VSN----TLAMGLAEMLGCFLALHLTFNLSERKWQWAGGFAIVV--GCIGSICWFLAEEDMPEVY 467
            ..|    .:..|..::...|:.:.....|..|..|   .|.:::  |.|.::.:..:|
  Rat   352 GVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQ---SFLLLLAGGAILALIFVPSE------- 406

  Fly   468 GLTLGLLMASLPQAAVACAQSMILACL----GELVPMEQRSCLSFSAVTWARVWQLSASFLTLLR 528
               :.||..:|......|. |...:||    .||.|...|......:..||||..:.|..:.:..
  Rat   407 ---MQLLRTALAVFGKGCL-SGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITG 467

  Fly   529 QVSPALSLSAFCLLVILGG 547
            ::.|.:....|....:|||
  Rat   468 ELQPFIPNVIFGTTALLGG 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	111/538 (21%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	32/145 (22%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	111/538 (21%)
		MFS	124..492	CDD:119392	89/403 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930