DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	552	Identity:	125/552 - (22%)
Similarity:	214/552 - (38%)	Gaps:	107/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DDVITHIMGNFGPWQLRSLLILFLCKI--PAAWFM----------ACIL------FTAPDLYPEE 105
            :||:..| |.|..:|...|.||:|.::  |..:.:          .|.|      |:|..  .|:
Zfish     4 EDVLREI-GGFNKFQFLVLYILWLPRVILPLHFLLHNFISGVPPHHCALPRLDGRFSASG--AEK 65

  Fly   106 EYKCDTTAFGPDVNSTVSLDHC--YVM-----------VNYGESAYAMRQCRK-FLY-TTGFHSL 155
            |......|.|...||..|...|  |.|           |.||..:.....|:. ::| .:.|.|.
Zfish    66 EELAQIVALGIPRNSDGSYSSCKMYTMPMDFDLNGDLSVLYGNRSNVSVPCQNGWVYDRSQFTST 130

  Fly   156 T-MEFDLVC--------LCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCS 211
            | .|:||||        |..||        ..|:.:|.|...:|......:.:.:..    .:.|
Zfish   131 TATEWDLVCDNKKLNQALATFF--------FIGVTMGAVVFGQLSDKFGRKPMIQVS----FVSS 183

  Fly   212 LLMGLVKDFSLHCGLRCLAAVSCCFMITSGQYI--------FGDITAGKYRVGTLILYDCFWALG 268
            .:.|:::.||....:..:|...|.|.:| |..|        :.|:   |:|..|..:....|::|
Zfish   184 AVFGIIEAFSSSYVMFAIARTLCGFALT-GMSITTVALCVEWTDV---KHRTFTGTIISLGWSVG 244

  Fly   269 LILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAAR 333
            .:||..||.....|:|:.|.||...||.:....|.|:|.||.|.:.:     :|.....|:..|:
Zfish   245 NMLLALLAYLIRDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGR-----VEEAQKYLINCAK 304

  Fly   334 TNGRMHKVSKELPQQLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMVVNT--GL 396
            .||: :..:|:|  .:|.|::..:......:..:|.: .|......:.:...:..|.|..|  |:
Zfish   305 MNGK-YSYTKKL--DIENLKKITIAEDSNKNHSYLDL-VRTPKLRKIVLCSGIFWFAVAFTYYGI 365

  Fly   397 LLHVRSFGREHLVSNTLAMGLAEM---LGCFLALHLTFNLSERKWQ-WAGGFAIVVGCIGSICWF 457
            ..::..||. ::.......|:.|:   :|.:|.|.   .:..|..| |:   .|:.|.:..:...
Zfish   366 SFNITGFGL-NIYLTQFIYGVIEVPAKVGTYLTLD---RIGRRNGQAWS---LIIAGALIGLNSV 423

  Fly   458 LAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSC-LSFSAVTWARVWQLSA 521
            :..|......|  :.::.....:||...|    .....||.|...|.| |.:::.. ||:....|
Zfish   424 IPTEFAAVRTG--IAVIGKGFSEAAFTIA----FLYTSELYPTVLRQCGLGYTSFI-ARIGGSLA 481

  Fly   522 SFLTLLRQV---SPALSLSAF-----CLLVIL 545
            ..:.|...:   .|.:..||.     |::.:|
Zfish   482 PMVILFEDIWHYGPPVVFSATAVFSGCVVFLL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	122/544 (22%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	31/141 (22%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	122/544 (22%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	87/405 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588731
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840