Protein Alignment CG4465 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 656
• Identity: 147/656 - (22%)
• Similarity: 230/656 - (35%)
• Gaps: 211/656 - (32%)

  Fly    59 DDVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACI----LFTAPDLY----------------P 103
            ||::..: |..|.:|.::.||  ||.:.||:...|:    |...||.:                |
Human     5 DDILEQV-GESGWFQKQAFLI--LCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRCGWSP 66

  Fly   104 EEEYKCDTTAFGPDVNSTVSLDHCYVMVNYGESAYA----------------MRQCRK-FLYTTG 151
            .||........||...:.:.....| .|::.:||.:                :..|:. ::|.|.
Human    67 AEELNYTVPGLGPAGEAFLGQCRRY-EVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTP 130

  Fly   152 FHSLTMEFDLVCL----CDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSL 212
            ..|:..||:|||.    .|.|.:......|||.|..|..|.:..|.|           |||
Human   131 GSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKL-----------CLL---- 180

  Fly   213 LMGLVKDFSLHCGLRCLAAVSCCFMITSGQY--------IFGDITAGKYRVG-TL---------- 258
                        |...:.|||...|..|..|        :.|.::.|.:..| ||
Human   181 ------------GTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSR 233

  Fly   259 ----ILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPW--TPDSPRWQLQHTKEA 317
                |:|...:.:||:.|.|||...|.|:.:.|.|  ||...:|||.:  .|:||||.|...:..
Human   234 RTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAV--SLPTFLFLLYYWCVPESPRWLLSQKRNT 296

  Fly   318 QLAIERTVGILLEAARTNGRMHKVSKELPQQLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAV 382
            :     .:.|:...|:.||::.....::....|::.|::   .|:...:......|:.||.|:.:
Human   297 E-----AIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKL---SPSFADLFRTPRLRKRTFILMYL 353

  Fly   383 HMALATFMVVNTGLLLHVRSFGREHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQWA-----G 442
            ..   |..|:..||:||:.:.. .:|..:.|...|.|:.|.|:|| :|.:...|.:..|     .
Human   354 WF---TDSVLYQGLILHMGATS-GNLYLDFLYSALVEIPGAFIAL-ITIDRVGRIYPMAMSNLLA 413

  Fly   443 GFA---------------IVVGCIG--------------------------------SIC----- 455
            |.|               |::.|:|                                |:|
Human   414 GAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGI 478

  Fly   456 ------------W-----FLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQR 503
                        |     .|.|:..|:....||    .|.||...|..:.::..|....:.||..
Human   479 ITPFIVFRLREVWQALPLILFEKQSPKKTRFTL----RSKPQNPRAPERDVLRRCRVGGMKMELS 539

  Fly   504 SC-------------------LSFSAVTWARVWQLSASFLTLLRQVSPALSLS-AFCLLVILGGL 548
            |.                   ::.|...|. ||.||.....||....|.||.: ||.|...:|.:
Human   540 SAEIPRRLHFSVFFLILAYPQINISPKEWF-VWALSYFVFFLLSSPKPWLSSTCAFDLGKAVGAI 603

  Fly   549 GTCCLV 554
            |...|:
Human   604 GIGYLI 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	144/645 (22%)
		MFS	169..>303	CDD:119392	40/158 (25%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	115/531 (22%)
		MFS	118..484	CDD:119392	92/407 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850