DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and CG4462

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_650849.1	Gene:	CG4462 / 42376	FlyBaseID:	FBgn0038752	Length:	573	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	260/552 - (47%)
Similarity:	358/552 - (64%)	Gaps:	35/552 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PHPKANNLADDND------------DDVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACILFTA 98
            ||...|.:.:|.|            .|||..::|:||.||||::||:||||||||||||||:||.
  Fly    15 PHILPNEMENDVDKRIATPPPAPAGSDVIADVVGDFGIWQLRTILIIFLCKIPAAWFMACIIFTG 79

  Fly    99 PDLYPEEEYKCDTTAFGPDVNSTVSL--DHCYVMVNYGESAYAMRQCRKFLYTTGFHSLTMEFDL 161
            |:|||..|:.|||:......||:.|:  :.|||:   .||.....:|.:|.|.:.|.||.|:|:|
  Fly    80 PELYPGSEFTCDTSYLTSSSNSSFSISDNQCYVL---DESTGTSSECEQFNYVSSFDSLIMQFNL 141

  Fly   162 VCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGLVKDFSLHCGL 226
            |||.|.||||:|||||||:|:|||..||:|..:|||..|..|....::|.::.|..:||||||..
  Fly   142 VCLRDIFVAWTQYWHLFGVLVGGVMGTKMMLGISPRSTYCVGAVAQILCGVVTGYARDFSLHCAF 206

  Fly   227 RCLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNAPSWQHIYLGVTL 291
            |||:||.|..|.|:||.||.|||||.:|:|.:||||.||::|:||||||:|...||..||:|:|.
  Fly   207 RCLSAVCCAIMFTAGQAIFADITAGMHRIGAIILYDTFWSIGVILLPGLSSFFNSWSLIYVGITF 271

  Fly   292 SLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSKELPQQLEELRERM 356
            ..::::.||.||||||||.|:|..: :.:|:....||.|.|..|.|..|:..:..||||:|.||:
  Fly   272 PTIMLILLLYWTPDSPRWLLRHAAD-RFSIDNVEQILREGAAINDRSFKIPPDFRQQLEQLSERL 335

  Fly   357 LEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMVVNTGLLLHVRSFGREHLVSNTLAMGLAEML 421
            ....|...|..||.|:|..| |:||.|:|||.|::...|:||::|||||::||.||:|||.:|::
  Fly   336 KAQPPPAPWTELWKGKRAKT-HMVAAHLALAFFVINFMGMLLNIRSFGRDYLVPNTIAMGFSEII 399

  Fly   422 GCFLALHLTFNLSERKWQWAGGFAIVVGCIGSICWFLAEED-MPEVYGLTLGLLMASLPQAAVAC 485
            |||||||.|...::.|||.||.|.|:.|.:|.:.|.....| |.....::|.:::|::|:|||:|
  Fly   400 GCFLALHFTLKHNKWKWQCAGVFNILAGILGCMGWIFTNADSMDADLKVSLWMIIATIPKAAVSC 464

  Fly   486 AQSMILACLGELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGLGT 550
            ||||||||:.||:|..::....||.|||||||.|||.|..:||::..|:||:::|:..||||:.|
  Fly   465 AQSMILACMNELMPANKKQLFVFSVVTWARVWLLSAPFFNVLRKIDTAMSLTSYCVFSILGGICT 529

  Fly   551 CCLVT---------------RDKEQPPVGAVV 567
            ..|:|               ..|||.|:.|.|
  Fly   530 SLLLTPRLSVSPVVPHLEQRNTKEQSPLNAPV 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	244/488 (50%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	71/133 (53%)
CG4462	NP_650849.1	2A0119	<126..532	CDD:273328	202/407 (50%)
CG4462	NP_650849.1	MFS	149..>284	CDD:119392	72/134 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BMR2
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	1	1.000	-	-		FOG0014281
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850