DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and CG17751

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_650816.3	Gene:	CG17751 / 42336	FlyBaseID:	FBgn0038717	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	135/572 - (23%)
Similarity:	216/572 - (37%)	Gaps:	137/572 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GNFGPWQLRSLLILFLCKIPAA--WFMACILFTAPDLYPEEEYKCDTTA-FGPDVNSTVSLDHCY 128
            |||||:|:..|.:.....|.::  :|...|:...|      .::|.... :.|  ||| ||..|.
  Fly    11 GNFGPYQILLLGLFGYTNIVSSLHYFSQTIISFTP------SHRCSRPEDYQP--NST-SLLSCS 66

  Fly   129 VMVNYGESAYAMRQCRK--FLYTTGFHSLTMEFDLVCLCDFFVAWSQYWHLFGLLIG----GVAA 187
            ||....|.     :|..  |...:.:.|:|.|.:.||...:.:|..|.:...|..:|    |..|
  Fly    67 VMQFDKEF-----KCTSWDFERESNYESITTELEWVCDDAYKLAVGQSFFFIGSALGSIFFGYLA 126

  Fly   188 TKLMRVLSPRQIYRTGIWCLLMCSLLMGLVKDF--SLHCGLRCLA---AVSCCFMITSGQYIFGD 247
            .::.|:.:          |:|  |.|.|...||  |....|...:   .:|..||.|  ||:...
  Fly   127 DRIGRLPA----------CVL--STLTGASGDFFTSFVGSLPWFSFTRFISGLFMDT--QYVLMY 177

  Fly   248 ITAGKY------RVGTLILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDS 306
            |...:|      ..|..|:...|:.:||::.|.:|....:|::.....:|..|.::....:..:|
  Fly   178 ILVFEYLSPQHRTFGLNIILGVFYCVGLMISPWIAIWVTNWRNYLWAASLPALGMLLFPVFLHES 242

  Fly   307 PRWQLQHTKEAQLAIERTVGILLEAARTNGRM--HKVSKELPQQLEELRERMLEPMPAVHWMHLW 369
            ..|.|...|     .|:....|...|:.|||.  ..|..|.   ::..||::..
  Fly   243 AEWLLTKGK-----FEKAEKSLRGVAKFNGRQVDDSVFDEF---IKHYREKLNN----------- 288

  Fly   370 MGQRRSTFHLVAVHMALATFMVVNTGLLL--HVRSFGREHLVSN---TLAMGL----AEMLG--- 422
             .|.:|:          .|||    |:|.  .:|.|....|:.:   |:|..:    .|.:|
  Fly   289 -SQNKSS----------DTFM----GMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISP 338

  Fly   423 ---------CFLALHLTFNLSERKWQWAG--GFAIVVGCIGSIC-----WFLAEEDMPEVYGLTL 471
                     |:|...||..|.:.|   .|  |.|.....:|:|.     :.:|..| |..|.:.|
  Fly   339 FKLFSYSGFCYLPAGLTIILFQNK---IGRKGMACASLFVGAIITAATGYLVATLD-PSDYSVLL 399

  Fly   472 GLLMASLPQAAVACAQSMILACLGELVP--MEQRSCLSFSAVTWARVWQLSASFLTLL---RQVS 531
            | .|.||.:.....|.........|::|  ::.|...:...|  ...:...:|::..|   .:..
  Fly   400 G-FMVSLGRYGAVVAYDAEAQYAAEIIPTSVKGRGVANIHVV--GNAFAFFSSYIIYLGTFYKPL 461

  Fly   532 PALSLSAFCLLVILGGLGTC-CLV---TRDKEQP---PVGAVVNKGQQLIAF 576
            |:|.:| |.||:     |.| ||.   |..|..|   ..|.:..||::...|
  Fly   462 PSLMIS-FILLI-----GACLCLALPETLHKNLPQNLEEGEMFAKGEKWYFF 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	126/541 (23%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	34/148 (23%)
CG17751	NP_650816.3	2A0119	11..490	CDD:273328	130/553 (24%)
CG17751	NP_650816.3	MFS	109..481	CDD:119392	97/432 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940