DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	145/571 - (25%)
Similarity:	224/571 - (39%)	Gaps:	129/571 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DDNDDDVITHIM---GNFGPWQLRSLLILFLCKIPAAWFMAC--ILFTAPDLYPEEEYKCDTT-- 112
            ||..||....::   |.||.:|.|.:.:.|:..|.:.:|:..  .|.||...|      |:|:
  Rat    44 DDRRDDKFASVLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHFLLTAQRPY------CNTSWI 102

  Fly   113 -AFGPD------VNSTV------SLDHC--YVMV------------NYGESAYAMRQCR-----K 145
             ..||:      :|.||      |...|  |:.|            ||.|:      |:     .
  Rat   103 LQVGPNLTEDEQLNLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTET------CKHGWIYP 161

  Fly   146 FLYTTGFHSLTMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMC 210
            |.:|   .|||.||||||..:......|...|.|:|.|.:    |...||.    :.|.:.:::.
  Rat   162 FAHT---RSLTNEFDLVCGNEPHEENGQTVFLSGILTGSL----LFGFLSD----KLGRYPIILL 215

  Fly   211 SLL--------MGLVKDFSLHCGLR-CLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWA 266
            |||        ...|..|..:...| .:|..|..:.|.|...:. :...|::|...:||..||:.
  Rat   216 SLLGILIFGFGTAFVNSFYQYLFFRFFVAQASVGYAICSVSLVM-EWLVGEHRAQAIILQHCFFT 279

  Fly   267 LGLILLPGLASNAPSWQHIYL--GVTL-SLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGIL 328
            :|:|||.|.|.....|:.::|  ||.: .|:..:::|   .:||||.:...|     :|....:|
  Rat   280 IGVILLTGFAYKINHWRLLFLLGGVPMFPLICNIWVL---QESPRWLMVKGK-----VEEAKKVL 336

  Fly   329 LEAARTNGRMHKVSKELPQQLEELRERMLEPMPA-VHWMHLWMGQRRSTFHLVAVHMALA----T 388
            ..||..|      .|.:|..|  |.|..|....| ...:..:..|     ||..|.:|:.    |
  Rat   337 CYAAEVN------KKTIPLNL--LNELQLPGKKAKASILDFYTNQ-----HLFKVVLAMGCVWFT 388

  Fly   389 FMVVNTGLLLHVRSFGREHLVSNTLAMGLAEMLGCFLALH------LTFNLSERKWQWAGGFAIV 447
            ...|:..|.|.::.||        |.:...:::.|..|:.      |......|||......::|
  Rat   389 VSYVSLTLSLKMKDFG--------LDIYFIQVVPCITAVPARLCCILLLEYFGRKWSLNLTLSLV 445

  Fly   448 V-GCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSC-LSFSA 510
            . .|:..:  |:.|    |:...|  :||..|.:.::|...|:......||:|...||. |...:
  Rat   446 TFTCLSLL--FVPE----ELKSTT--ILMLVLGEFSMAGTVSIFFIYTAELLPTILRSTGLGMVS 502

  Fly   511 VTWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGLGTCCLVTRDKEQP 561
            :.|...   :.|.|.:.:|....|.:...||..|| .|....||.....||
  Rat   503 IAWTAG---AISSLAIFKQTKTQLPIFFCCLCCIL-ALCFSSLVPETGNQP 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	137/546 (25%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	37/145 (26%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	109/437 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010