Protein Alignment CG4465 and Slc22a22

DIOPT Version :10

• Sequence 1: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_001013969.1
• Gene: Slc22a22 / 299944
• RGDID: 1304605
• Length: 555
• Species: Rattus norvegicus
• Alignment Length: 577
• Identity: 131/577 - (22%)
• Similarity: 212/577 - (36%)
• Gaps: 175/577 - (30%)

  Fly    60 DVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKCDTTAFGPDVNSTVSL 124
            |.|.|.:|:.|.:|:..:::|.:..:.::.......|||                      .:..
  Rat     4 DEILHHVGDRGRFQIWMIVVLNILSMVSSLHDVIENFTA----------------------AIPA 46

  Fly   125 DHCYVMV---NYGESAYAM--------------------RQCRKFLYT----------------- 149
            .||.|.:   :..|.:.||                    .|||:|.:.
  Rat    47 HHCSVNLLDTSRSEISMAMNLTTEAMMKVSIPMGPNQKPEQCRRFRHPQWQFIDSNISTSNSTEL 111

  Fly   150 ---------TGFHS-----LTMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIY 200
                     |..||     :..|:||||....|..::|...|.|..:    |.....::|.
  Rat   112 ETEPCLDGWTYDHSVFTSTIVTEWDLVCDFQSFKYYAQATSLAGHFV----AAPFCGIISD---- 168

  Fly   201 RTGIWCLLM-CSLLMGL-------VKDFSLHCGLRCLAAVS-------CCFMITSGQYIFGDITA 250
            |.|...||| |||..|:       |.:|||:|.||.|::.|       |..::.       :.|:
  Rat   169 RFGRKPLLMYCSLAYGILGTCCAFVPNFSLYCVLRFLSSASASTVGMNCLILVL-------EETS 226

  Fly   251 GKYRVGTLILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTK 315
            .::....::|...|.:.||..|.|||.....|..|.|...|...:...|..|.|:|.|| |..|.
  Rat   227 VQWHATVIVLSGLFSSTGLAGLGGLAYVLSDWHLIQLTSALPYFIFFILFCWVPESARW-LMITG 290

  Fly   316 EAQLAIERTVGILLEAARTNGRMHKVSKELPQQL--EELRERMLEPMPAVHWMHLWMGQRRSTFH 378
            :...|::.    |...|..||:     |::.|.|  |:||.::.|.:.:
  Rat   291 KTDQALKE----LQRIASINGK-----KDIAQNLTTEDLRSKVKEDVCS---------------- 330

  Fly   379 LVAVHMALATFMVVNT---------------------GLLLHVRSFGREHLVSNTLAMGLAEMLG 422
             ...|.::.. :::|.                     ||||.|...|:...|:..| :|:.::..
  Rat   331 -TVKHFSIKD-IIINPMIRKIVLCYSSVLFAELFSIFGLLLDVHMLGKNIFVTQIL-LGVIDIPS 392

  Fly   423 CFLALHLTFNLSERK----WQWAGGFAIVVGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAV 483
            ..|...:..|:..|.    ..:|.|     ||| :|..||:|    ::|.|.|.:.:  |.:...
  Rat   393 KSLTYFILRNVRRRPLIAFLLFATG-----GCI-TITMFLSE----DMYVLRLAIFI--LGKGCF 445

  Fly   484 ACAQSMILACLGELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVSPALSLSAFC 540
            |...|:..|...||.|:..||.|:...::.||:..: .|.|||:.:....|....||
  Rat   446 AAFISINTAYCNELSPVPLRSTLNGIYISVARLASV-LSALTLVTRKYFVLLPMIFC 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	MFS_SLC22	143..553	CDD:340875	114/471 (24%)
Slc22a22	NP_001013969.1	MFS_OAT	109..516	CDD:340932	111/450 (25%)