DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_062142.1	Gene:	Slc22a5 / 29726	RGDID:	3702	Length:	557	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	113/558 - (20%)
Similarity:	213/558 - (38%)	Gaps:	129/558 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 DDDVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKCDTTAFGPDVNSTV 122
            |.|.:|..:|.:||:|.....:|....||..:....|:|.|    ...|::|       .|..||
  Rat     3 DYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLA----GTPEHRC-------LVPHTV 56

  Fly   123 SLDHCY----VMVNYGESAYAMRQCRKFLYTT--GFHSLTM------------------------ 157
            :|...:    :.:...:.....:.||::...|  .|.:|.:
  Rat    57 NLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNK 121

  Fly   158 ---------EFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLL 213
                     |:||||..|:....:......|:|:|...:.:|......:.:          ..|.
  Rat   122 DVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNV----------LFLT 176

  Fly   214 MGLVKDFSLHCGLRCLAAVSCCF--------MITSGQ-------YIFG-DITAGKYRVGTLILYD 262
            ||:...||.      |...|..|        ::..||       ::.| :|.:...|:....|..
  Rat   177 MGMQTGFSF------LQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGV 235

  Fly   263 C-FWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQ--HTKEAQLAIERT 324
            | |:|.|.::||..|.....|:.:.|.:|:..::...|..:.|:||||.:.  ..|||::
  Rat   236 CIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEV----- 295

  Fly   325 VGILLEAARTNGRMHKVSKELPQQLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATF 389
              |:.:||:.||.:...:...|.:|::|..:    .|..|  |::...|.....::.: |::..:
  Rat   296 --IIRKAAKFNGIVAPSTIFDPSELQDLNSK----KPQSH--HIYDLVRTRNIRIITI-MSIILW 351

  Fly   390 MVVNTGLLLHVRSFG--------REHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQWAGGFAI 446
            :.::.|.      ||        ...:..|...:...|:....||..|..:|..|   ::...|:
  Rat   352 LTISVGY------FGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRR---YSISAAL 407

  Fly   447 VVGCIGSICWFLAEEDMP-EVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSCLSFSA 510
            .:|  ||:..|:  :.:| |::.|:..|:|..  :..:..|.||:.....||.|...|:.....:
  Rat   408 FLG--GSVLLFI--QLVPSELFYLSTALVMVG--KFGITSAYSMVYVYTAELYPTVVRNMGVGVS 466

  Fly   511 VTWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGL 548
            .|.:|:..:.:.:...|.      :...|...:::|.|
  Rat   467 STASRLGSILSPYFVYLG------AYDRFLPYILMGSL 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	110/549 (20%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	29/150 (19%)
Slc22a5	NP_062142.1	2A0119	12..520	CDD:273328	110/549 (20%)
		MFS	123..510	CDD:119392	89/427 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..557
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840