DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	556	Identity:	111/556 - (19%)
Similarity:	222/556 - (39%)	Gaps:	92/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKC-----DTTAFGPDVN 119
            |:|..| |:.|.:|:..::.:.:|...:|.......|||  ..|  .::|     |......:.:
Mouse     5 DLIIQI-GSLGRFQILHMIFVLICHALSAPHTLLENFTA--AIP--SHRCWVPILDNDTASDNGS 64

  Fly   120 STVSLDHCYVMVNYGESAYAMRQCRKF-------LYTTG-----------------------FHS 154
            ..:|.|....:....:|.....:||::       |:..|                       |.|
Mouse    65 RILSQDDLLRISIPLDSNLRPDKCRRYIQPQWHLLHLNGTFPTVTEPDTEPCVDGWVYDQSTFLS 129

  Fly   155 LTM-EFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGLVK 218
            .|: ::||||......:.:::.::.|:.||.:....|......:.|:...:..:.:....:....
Mouse   130 TTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKMAITETCVAFAP 194

  Fly   219 DFSLHCGLRCLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNAPSWQ 283
            .|.::|.||.|:.:....:.|:...:..:.|:.|::...:.|......:|..||.|||....:|.
Mouse   195 SFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASGVGQTLLGGLAFAFRNWH 259

  Fly   284 HIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSKELPQQ 348
            |:.|.:::.:.:::....|..:|.||.:...|.     ::::..|.:||..| |:......|..:
Mouse   260 HLQLALSVPMFLLLIPTRWLSESARWLIMANKP-----QKSLKELKKAACVN-RIKNSGDALTLE 318

  Fly   349 L------EELRERMLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMVVNT--GLLLHVRSFGR 405
            :      |||.....:|.|    :.|:   |..........::...|:.|.:  |||:::
Mouse   319 VVKTIMKEELEAAQTKPSP----LDLF---RTPNLRKRICLLSFVRFVSVMSLLGLLINI----- 371

  Fly   406 EHLVSNTLAM----GL----AEMLGCFLALHLTFNLSERKWQWAGGFAIVVGCIGSICWFLAEED 462
            ::|.:|...:    |:    |.:||.|...::...:::..:....|.:|:     ::.:...|..
Mouse   372 QYLSNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISIL-----AVVFLPQEMQ 431

  Fly   463 MPEVYGLTLGLLMASLPQAAVACAQ-SMILACLGELVP-MEQRSCLSFSAVTWARVWQLSASFLT 525
            :..|:..|||        .|::.|. :..|....|||| :.:.:.|....:..:....|| ..|.
Mouse   432 ILRVFLSTLG--------GAISSASITSTLVHANELVPTIIRATALGVVGIAGSAGGALS-PLLM 487

  Fly   526 LLRQVSPALSLSAFCLLVILGGLGTCCLVTRDKEQP 561
            :|...|.:|....:.:|..|||| ...|:...|.||
Mouse   488 ILTTYSASLPWIIYGILPFLGGL-VALLLPETKNQP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	104/539 (19%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	23/133 (17%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	108/549 (20%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843638
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840