DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	521	Identity:	115/521 - (22%)
Similarity:	204/521 - (39%)	Gaps:	83/521 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 MGNFGPWQLRSLLILFLCKIPAAWFMACILFTA--PDLY----PEEEYKCDTTAFGPDVNSTVSL 124
            :|:.||:|...:.:|.|..:..|......:|||  ||.:    |....:......||:...
Mouse    10 VGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHCRPPPNASLEPWVLPLGPNGKP---- 70

  Fly   125 DHCYVMVNY------GESAYAMRQCRK-FLYTTGFHSLTMEFDLVCLCDFFVAWSQYWHLFGLLI 182
            :.|...|:.      .::..|...|.. ::|.:...::..|:||||..:.....:|...:.|:|:
Mouse    71 EKCLRFVHLPNASLPNDTQGATEPCLDGWIYNSTRDTIVTEWDLVCGSNKLKEMAQSVFMAGILV 135

  Fly   183 GGVAATKLMRVLSPRQIYRTGIWCLLMC-----------SLLMGLVKDFSLHCGLRC-LAAVSCC 235
            ||....:|......:.|.   .|..|:.           ||.:.::  |...||  | ::.:|..
Mouse   136 GGPVFGELSDRFGRKPIL---TWSYLLLAASGSSAAFSPSLTVYMI--FRFLCG--CSISGISLS 193

  Fly   236 FMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLL 300
            .:|.:.:::   .|:.:....|.|.| |: .:|..:|||||...|.|:.:.|.|:.:..:...|.
Mouse   194 TIILNVEWV---PTSTRAISSTTIGY-CY-TIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLLS 253

  Fly   301 PWTPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMHKVSKELPQQL--EELRERMLEPMPAV 363
            .|.|:|.||.:...|     ..:.:..|...|..||:     ||..::|  |||:..:.:.:.:.
Mouse   254 WWVPESIRWLVLSGK-----FSKALKTLQRVATFNGK-----KEEGEKLTVEELKFNLQKDITSA 308

  Fly   364 HWMH----LWMGQRRSTFHLVAVHMALATFMVVNTGLLLHVRSFGREHLVSN----TLAMGLAEM 420
            ...:    |:   |.|....|...::||.|.   ||...:..:.|.|....|    .:..|..::
Mouse   309 KVKYGLSDLF---RVSILRRVTFCLSLAWFA---TGFAYYSLAMGVEEFGVNIYILQIIFGGVDI 367

  Fly   421 LGCFLALHLTFNLSERKWQWAGGFAIVVGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVAC 485
            ...|:.:.....|..|..|   ||.:::..:..:.......:|.        ||..:|......|
Mouse   368 PAKFITILSISYLGRRITQ---GFLLILAGVAILALIFVSSEMQ--------LLRTALAVFGKGC 421

  Fly   486 AQSMILACL----GELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVSPALSLSAFCLLVILG 546
            . |...:||    .||.|...|......:..||||..:.|..:.:..::.|.:....|..:.:||
Mouse   422 L-SGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLG 485

  Fly   547 G 547
            |
Mouse   486 G 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	115/520 (22%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	33/145 (23%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	115/520 (22%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840