DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	572	Identity:	129/572 - (22%)
Similarity:	233/572 - (40%)	Gaps:	101/572 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DVITHIMGNFGPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKC------DTTAFGPDV 118
            |::..: |:.|.:|:..:..:.:..|..:.......|||  :.|  .::|      :.|..|.|
  Rat     5 DLLNQV-GSLGRFQILQMTFILIFNIIISPHSLLENFTA--VIP--NHRCWVPILDNDTVSGND- 63

  Fly   119 NSTVSLDHCYVMVNYGESAYAMRQCRKF-------LYTTG-FHSLT------------------- 156
            |..:|.|....:....:|.....:||:|       |:..| |.|:|
  Rat    64 NGNLSQDDLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVDGWVYDQSTFL 128

  Fly   157 ----MEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGLV 217
                .|:||||......:.:::..|.|:|:|.:....|..        |.|...:|:|:.|...|
  Rat   129 STIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTD--------RFGRRLILICASLQMAV 185

  Fly   218 KD--------FSLHCGLRCLAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCFWALGLILLPG 274
            .:        |.::|.||.||.:|...::|:...:..:.|..|::.....|..|..|:|..:|.|
  Rat   186 TETCAAFAPTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQTVLAG 250

  Fly   275 LASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAARTNGRMH 339
            ||....:|.|::|.:::.:..::....|..:|.||.:...|     :::.:..|::.|..||.
  Rat   251 LAFTVRNWHHLHLAMSVPIFFLLVPTRWLSESARWLIMTNK-----LQKGLKELIKVAHINGM-- 308

  Fly   340 KVSKELPQQLEELRERMLEPMPAVHW-MHLWMGQRRSTFHLVAVHMALATFMVVNT--GLLLHVR 401
            |.|.:: ..:|.:|..|.|.:.|... ..||...|..........::|..|:|..:  |||::.
  Rat   309 KNSTDV-LTIEVVRTIMKEELEASQTKSSLWDLFRTPNLRKRICLLSLVRFVVWLSVIGLLINF- 371

  Fly   402 SFGREHLVSNTL----AMGL----AEMLGCFLALHLTFNLSERKWQWAGGFAIVVGCIGSICWFL 458
                :||..|..    .:|:    |.::|.||..||...:|:.       |.|.:..|..:....
  Rat   372 ----QHLRINVFLLQCLLGIITIPANLVGIFLVNHLGRRISQL-------FIISLFGISILAIIF 425

  Fly   459 AEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVP-MEQRSCLSFSAVTWARVWQLSAS 522
            ..::|.     .|.:::|:........:.|..|....||:| :.:.:.|....:..:....||..
  Rat   426 VPQEMQ-----ILRMVLATFGGVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPL 485

  Fly   523 FLTLLRQVSPALSLSAFCLLVILGGLGTCCLVTRDKEQP---PVGAVVNKGQ 571
            |: :||..|.:|....:.:|..|||| ...|:...|.||   .:..|.|:|:
  Rat   486 FM-ILRTYSDSLPWIIYGVLSFLGGL-VVLLLPETKNQPLPDSIQDVENEGR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	121/542 (22%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	32/141 (23%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	125/553 (23%)
		Aldolase_II	39..>85	CDD:294146	12/50 (24%)
		MFS	125..506	CDD:119392	93/414 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840