DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and K05F1.6

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	709	Identity:	157/709 - (22%)
Similarity:	248/709 - (34%)	Gaps:	229/709 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NLYRGW------MPNIR------RNSPAPL------DLGHMAHSFTCTDPK-------------- 37
            ||::.:      :|::|      ||:.|.:      .:.|.....|.|.|:
Worm    96 NLHKSFAASDTLLPHMRVVADEMRNTSASVTAEPEPSVSHAPSVLTVTAPEDRNMYQSDISMYGR 160

  Fly    38 --------ANEVSPQTPHPKANNL--------------ADDNDDDVITHIMGNFGPWQLRSLLIL 80
                    ..|:..|  |.|...:              .|..|.:.|.:|:|....||:...:::
Worm   161 QGHKPSFSTREIREQ--HQKVQQIYRDVNKKERKEGKPTDPIDFEGILNIIGGCRWWQIWIYVLI 223

  Fly    81 FLCKIPAAWFMACILFTAPDLYPEEEYKC---------DTTAFG------------------PDV 118
            .|.:||.|.|...:::...|    .|::|         |||...                  |:.
Worm   224 ALQQIPHAMFNLNVVYMMYD----PEFQCMVPGFNDTNDTTISSHGPYLWGVDDIKNISFVFPNA 284

  Fly   119 NS--TVSLDHCYVMVNYGESAYAMRQCRKFLYTT----------------GFH--------SLTM 157
            ||  ....|.||.   |..|....||.|:....|                .:|        ::..
Worm   285 NSDGAYQRDSCYF---YERSEERYRQLRRMPLETAMSEAWKDVAPKKKCQAYHFEKDVMVETIVT 346

  Fly   158 EFDLVCLCDFFVAWSQYWH---------LFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLL 213
            :|:|||     .:|....|         |.|.::||:|:.|:.|  .| .|...||     .|.:
Worm   347 DFNLVC-----DSWFAKGHAHMFYSIGYLLGCVLGGIASDKIGR--KP-TIIGFGI-----LSSM 398

  Fly   214 MG-------------LVKDFSLHCGLRC-LAAVSCCFMITSGQYIFGDITAGKYR--VGTLILYD 262
            :|             |::..|..|.... |||.:.|.          :||..|||  ||:::  .
Worm   399 LGVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCM----------EITGTKYRAMVGSML--Q 451

  Fly   263 CFWALGLILLPGLASNAPSWQHI-YLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVG 326
            ..||||..||..:|....||:.| .:...|..:.|:|:.. .|:||||.:     .|..:.....
Worm   452 APWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICS-IPESPRWLM-----VQNRVSEAEE 510

  Fly   327 ILLEAARTNG---RMHKVSK--ELPQQLEEL--RERMLEPMPA--VHWMHLWMGQ--RRSTFHLV 380
            ::.:|.|...   .|...||  .||..||.:  |||.|.....  :.::.|:..:  |..|..:.
Worm   511 VIRKACREPPFPFNMCTTSKCGNLPSDLELVSHRERKLNKKNGGKIGFLDLFTMKELRYRTISVC 575

  Fly   381 AVHMALATFMVVNTGLLLHVRS---------FGREHLVSNTLAMGLAEM-----------LGCFL 425
            .|.||.|   :|..||::.:..         .|..|| :|.:| |..|:           ||...
Worm   576 IVFMATA---LVYYGLVMALSDQSAPGRTLFTGYFHL-NNGIA-GAIEIPTLFACVWMMQLGRKK 635

  Fly   426 ALHLTFNLSERKWQWAGGFAIVVGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMI 490
            ||.||...|        |..|:|..:..:...         |.|.|..:.  ..:.||..|.:::
Worm   636 ALMLTLITS--------GLFIIVAMLSMVSGH---------YMLALAFMY--FGKIAVQGAFNIL 681

  Fly   491 LACLGELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVS-PALSLSAFCLLVILGGL 548
            .....||.|...|:.........||.....:|::.||..:| |.:.:..|.:..:..|:
Worm   682 YIFTSELYPTVVRNTAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAGM 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	138/593 (23%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	42/159 (26%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	112/463 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950