Protein Alignment CG4465 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 103/498 - (20%)
• Similarity: 163/498 - (32%)
• Gaps: 165/498 - (33%)

  Fly   142 QCRKF----------------------------------LYTTGFHSLTMEFDLVCLCDFFVAWS 172
            |||:|                                  ::|:   ::..:::|||........:
Human    87 QCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTS---TIVAKWNLVCDSHALKPMA 148

  Fly   173 QYWHLFGLLIGGVA--------ATKLMRVLSPRQIYRTG----------IWCL---LMCSLLMGL 216
            |..:|.|:|:|..|        ..:|:...|..|:...|          ::||   |:...:.|:
Human   149 QSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGV 213

  Fly   217 VKDF-------------SLHCGLRC----LAAVSCCFMITSGQYIFGDITAGKYRVGTLILYDCF 264
            :.:.             .||.|.|.    |.||.             :.||.:.|...:.|....
Human   214 MMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVM-------------EWTAARARPLVMTLNSLG 265

  Fly   265 WALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILL 329
            ::.|..|...:|.....|..:.|.|::...:......|..:|.||.|. |......::.    |.
Human   266 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLT-TGRLDWGLQE----LW 325

  Fly   330 EAARTNGRMHKVSKELPQ-QLEELRERMLEPMPAVHWMHLWMGQRRSTFHLVAVHMALATFMVVN 393
            ..|..||:........|: .|..:||            .|.|||..::.
Human   326 RVAAINGKGAVQDTLTPEVLLSAMRE------------ELSMGQPPASL---------------- 362

  Fly   394 TGLLLHVRSFGREHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQWAGGFAIVVGCIGS----I 454
             |.||.:... |.....:||         |:.|...||          .|.|:.:..:||    :
Human   363 -GTLLRMPGL-RFRTCISTL---------CWFAFGFTF----------FGLALDLQALGSNIFLL 406

  Fly   455 CWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILA--CL--GELVPMEQ---RSCLSF---- 508
            ..|:...|:|...|   .||:.|........|.|::||  |:  ..|||.|.   ||.|:.
Human   407 QMFIGVVDIPAKMG---ALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLG 468

  Fly   509 ---SAVTWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGL 548
               :|.|...::. |..|.|:||..:..|...|.....|||.|
Human   469 GVGAAFTCITIYS-SELFPTVLRMTAVGLGQMAARGGAILGPL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	103/498 (21%)
		MFS	169..>303	CDD:119392	31/171 (18%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	103/498 (21%)
		MFS	122..541	CDD:119392	99/463 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153240
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840