DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4465 and slc22a8

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	132/586 - (22%)
Similarity:	206/586 - (35%)	Gaps:	151/586 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GNFGPWQLRSLLIL-FLCKIPAAW-----FMACILFTAPDLYPEEEYKCDTTAFGPDVNSTVSL- 124
            |..|.:|:..:::| |...:.|:.     |.|.|    ||      :||.....|...|||...
Frog    11 GGMGRFQITQVVLLCFPILLMASHNLLQNFSAAI----PD------HKCKANDTGYQSNSTDETG 65

  Fly   125 --------------DHC--YVMVNY----------GESAYAMRQCRKFLYTTGFH--------SL 155
                          |.|  ||.:.:          ..|..|.|.|     |.|:.        ::
Frog    66 YERLSAPLDANGQPDRCLEYVEIQWRMVGSNSTWNNSSELATRPC-----TIGWEYSKDEFSSTI 125

  Fly   156 TMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWCLLMCSLLMGLVKDF 220
            ..|:||||........:|..::.|:|:|.:    ::..||.|.    |...||:.|.       |
Frog   126 ITEWDLVCGRKTRRQLAQSIYMGGVLVGAI----ILGGLSDRY----GRRALLIWSY-------F 175

  Fly   221 SLHCGLRCLAAVS------CCFMITSGQYIFG---DITA-------GKYRVGTLILYDCFWALGL 269
            .|.....| ||.|      |.|...:|..:.|   :.||       .:.|..|..|....:..|.
Frog   176 QLAVSGVC-AAFSPNYLSYCIFRFLTGMALSGIGLNTTALIVEWVPTRVRTVTGTLAGFSYTAGQ 239

  Fly   270 ILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERTVGILLEAART 334
            :||.|||.....|:.:.|.|:|...:......|.|:|.||.:...|.     |:.|..:.:.|..
Frog   240 LLLAGLAYGMRDWRWLQLCVSLPFFIYFLYAWWFPESARWLVLSGKP-----EKAVKEIRKVANL 299

  Fly   335 NGRMHKVSKELPQQLEELRERMLEPMPAVHWMHLWMG-QRRSTFHLVAVHMALATFMV--VNTGL 396
            ||:..:..|   ..||.|:..|::.:.:....:..:. .|.:|...::..::|..|..  ...||
Frog   300 NGKKEEGEK---ITLESLKSEMIKELASAKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGL 361

  Fly   397 LLHVRSFG---------------REHLVSNTLAMGLAEMLGCFLALHLTFNLSERKWQWAGGFAI 446
            .:.::.|.               ...|||.|..:.:......|::|.|            ||.||
Frog   362 AMDLQKFNVSIYLIQVIFGAVDFPAKLVSATAMIYVGRKFTQFMSLIL------------GGIAI 414

  Fly   447 VVGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPMEQRSCLSFSAV 511
            :...      |:..|..      |:...:|...:..:|.:.|.|.....||.|...|........
Frog   415 IANI------FVPNELQ------TVRTSLAVFGKGCLAASFSCIFLYTTELYPTVIRQSGLGMCS 467

  Fly   512 TWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGL----GTCCLV---TRDKEQPPVGAVVNK 569
            |.||:..:.|..:.:|.::.|      |..|:|.||.    |.|...   |.:|..|.....|.|
Frog   468 TMARIGGIVAPLVKILGELYP------FVPLLIYGGAPIISGLCVFFLPETVNKPLPDTIEEVEK 526

  Fly   570 G 570
            |
Frog   527 G 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	126/564 (22%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	36/149 (24%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	104/463 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010