DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4465 and slc22a6

DIOPT Version :9

Sequence 1:	NP_650847.1	Gene:	CG4465 / 42374	FlyBaseID:	FBgn0038750	Length:	577	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	117/519 - (22%)
Similarity:	193/519 - (37%)	Gaps:	92/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IMGNF------GPWQLRSLLILFLCKIPAAWFMACILFTAPDLYPEEEYKCDTTAFGPDVNSTVS 123
            |.|:|      ||| ||:|:.:    .|...|..|:.:|.|      :|......|..:|:. :.
Frog    51 INGSFEETNFTGPW-LRALVPM----KPTGEFSKCLRYTTP------QYHLLMDNFTQNVDE-LE 103

  Fly   124 LDHCYVMVNYGESAYAMRQCRKFLYTTGFHSLTMEFDLVCLCDFFVAWSQYWHLFGLLIGGVAAT 188
            .:.|.....|..|.:|             .::..::||||........:|..::.|:|:|.|...
Frog   104 TETCVDGWVYDHSEFA-------------STIITQWDLVCNHRRMRQVAQSIYMAGVLVGSVVFG 155

  Fly   189 KLMRVLSPRQIYRTGIWCLLMCSLLMGLVKDFS----LHCGLRCLAAVSCC-FMITSGQYIFGDI 248
            .|......|.:   .||..|..| :.|:...||    .:|..|.|...:.. .::.|...|...|
Frog   156 GLSDKFGRRPL---NIWSNLQMS-VTGICAAFSPNYIWYCIFRFLTGTALSGIVLNSYSLIVEWI 216

  Fly   249 TAGKYRVGTLILYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQH 313
            ..|. |..|.......:.:|.::|.|||.....|..:.|..:|..........|.|:|.||.:..
Frog   217 PTGN-RAFTSTATGYCYTMGQLVLVGLAFMIRDWHWLQLAASLPFFFYFLYSWWIPESGRWLVLS 280

  Fly   314 TKEAQLAIERTVGILLEAARTNGRMHKVSKELPQQL--EELRERMLEPMPAVHWMHLWMGQRRST 376
            .|.     |.....|.:.|:.||:     ||..::|  |.|:..|...:.|         .:.||
Frog   281 GKP-----EVACKALKKVAKINGK-----KEAGEKLTVEVLKSSMQREISA---------SKHST 326

  Fly   377 FHLVAV----HMALATFMVVNT---------GLLLHVRSFGREHLVSNTLAMGLAEMLGCFLALH 428
            :.::.:    .:...:|.:..|         ||.|.::|||....:.. :..|..::...|.:..
Frog   327 YSVLDLVRTPVVRRISFCISCTWFSTSFAYYGLALDLQSFGVSIYIIQ-IIFGTVDIPAKFFSYF 390

  Fly   429 LTFNLSERKWQ----WAGGFAIVVGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSM 489
            :...:..|..|    ...|.||:|    :||       :|:.| .|:...||...:..:|.:.:.
Frog   391 VMTYIGRRVLQALTLILAGIAILV----NIC-------VPQDY-QTVRTSMAVFGKGCLAASFNC 443

  Fly   490 ILACLGELVPMEQRSCLSFSAVTWARVWQLSASFLTLLRQVSPALSLSAFCLLVILGGLGTCCL 553
            :....|||.|...|..........||:..:.|....:...:..:|.|..|..|.||.|:..|.|
Frog   444 LFLYTGELYPTVIRQSGMGLGTMMARLGGIIAPLAQMTGDIYHSLPLIIFGCLPILSGIAGCFL 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	2A0119	67..553	CDD:273328	115/515 (22%)
CG4465	NP_650847.1	MFS	169..>303	CDD:119392	31/138 (22%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	100/456 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D704438at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010